The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
• Provides essential background knowledge for designing and interpreting studies with genetically modified mice • Includes many examples of experimental problems, providing help with experimental design and troubleshooting • Each chapter reviews current knowledge about one specific type of behaviour, pointing the reader towards the most important studies in the extensive literature
Contents
Contributor list; Part I. General: 1. Current status of the field W. E. Crusio and R. T. Gerlai; 2. Natural neurobiology and behavior of the mouse: relevance for behavioral studies in the laboratory H. P. Lipp and D. P. Wolfer; 3. Ethogram R. T. Gerlai and W. E. Crusio; 4. Replicability and reliability of behavioral tests D. Wahlsten and J. C. Crabbe; Part II. Perception: 5. Audition J. F. Willott; 6. Behavioral measurement of mouse visual function G. T. Prusky and N. M. Alam; 7. Tactile system and nociception S. B. Smith and J. S. Mogil; 8. Olfactory acuity in Mus musculus H. Schellinck and B. Slotnick; 9. Taste genetics J. Boughter; Part III. Autonomous and Motor Behaviors: 10. Motor coordination in inbred mouse strains and the crucial role of the cerebellum R. Lalonde and C. Strazielle; 11. Reflex development F. Cirulli and E. Alleva; 12. Feeding and drinking R. J. Bodnar, S. R. Lewis and B. Kest; 13. Lateralization F. G. Biddle; 14. Rhythms and sleep: circadian and seasonal activity patterns B. Possidente; 15. Exploratory behavior W. E. Crusio; 16. Strains, SNPs and selected lines: genetic factors influencing variation in murine anxiety-like behavior A. Holmes; 17. Genetic influences on infant mouse ultrasonic vocalizations R. Benno and M. E. Hahn; 18. Startle behavior and prepulse inhibition C. F. Plappert and P. K. D. Pilz; 19. Mouse models of stress-induced depression-like behavior: stress vulnerability and antidepressant response as traits H. Gershenfeld; 20. Behavioral phenotyping of mouse grooming and barbering P. R. Canavello, J. M. Cachat, P. C. Hart, D. L. Murphy and A. V. Kalueff; Part IV. Social Behavior: 21. Social interaction C. Blanchard, J. Crawley, H. Arakawa and R. Blanchard; 22. Mouse sex: sexual differentiation and sexual behavior in Mus musculus L. Niel and D. A. Monks; 23. Nest-building behavior and the genetic correlation structure of adaptive phenotypes in house mice Abel Bult-Ito; 24. Aggression F. Sluyter, S. de Boer and S. C. Maxson; Part V. Learning and Memory: 25. Latent inhibition T. J. Gould and S. F. Logue; 26. Executive function: response inhibition, attention, and cognitive flexibility S. F. Logue and T. J. Gould; 27. Water navigation tasks D. P. Wolfer, G. Colacicco and H. Welzl; 28. Active and passive avoidance I. Branchi and L. Ricceri; 29. Radial maze W. E. Crusio and Herbert Schwegler; 30. Other mazes T. P. O'Leary and R. E. Brown; 31. Cued and contextual fear conditioning R. M. Gerlai; 32. Taste and odor H. Welzl and D. P. Wolfer; 33. Object recognition in the mouse E. Dere, A. Zlomuzica and J. P. Huston; Index.
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