Skip to content
Cart

Your Cart

×

You have 0 items in your cart.

Register Sign in Wishlist

Dance to the Tune of Life
Biological Relativity

£17.99

  • Date Published: December 2016
  • availability: In stock
  • format: Hardback
  • isbn: 9781107176249

£ 17.99
Hardback

Add to cart Add to wishlist

Other available formats:
eBook


Looking for an inspection copy?

This title is not currently available on inspection

Description
Product filter button
Description
Contents
Resources
Courses
About the Authors
  • In this thought-provoking book, Denis Noble formulates the theory of biological relativity, emphasising that living organisms operate at multiple levels of complexity and must therefore be analysed from a multi-scale, relativistic perspective. Noble explains that all biological processes operate by means of molecular, cellular and organismal networks. The interactive nature of these fundamental processes is at the core of biological relativity and, as such, challenges simplified molecular reductionism. Noble shows that such an integrative view emerges as the necessary consequence of the rigorous application of mathematics to biology. Drawing on his pioneering work in the mathematical physics of biology, he shows that what emerges is a deeply humane picture of the role of the organism in constraining its chemistry, including its genes, to serve the organism as a whole, especially in the interaction with its social environment. This humanistic, holistic approach challenges the common gene-centred view held by many in modern biology and culture.

    • Proposes a new theory of biology - biological relativity - which will appeal to those who find the gene-centric view narrow and even a little dehumanising
    • Complexity in biology is made accessible and technical language and equations are avoided
    • Controversial aspects are fully documented in notes with references to the original material to enable readers to explore the technical, scientific or philosophical basis of new or controversial aspects
    Read more

    Reviews & endorsements

    'Among its many merits, this remarkable book deserves to become a classic text in the philosophy of science. Almost alone among philosophers of science, Noble is a practising scientist; and unusually among practising scientists, he is an accomplished philosopher. His book brings out, with unparalleled clarity, how the scientific endeavour involves not only empirical inquiry but also conceptual structure. Noble shows how, on the negative side, popular presentations of sound biological results may be vitiated by bad metaphysics, and how, on the positive side, science and philosophy may extend the boundaries of knowledge by a unified epistemology. He ends, however, with a salutary warning that there may well be a limit to the human capacity to know the answers to ultimate questions.' Sir Anthony Kenny, University of Oxford

    'I think this a marvellous book. Denis Noble emphasises that genes, organs and systems dance to the tune of the organism its social and physical environment. He sets the relativity of biology in a remarkable scientific sweep, ranging from cosmology to human belief systems. He reminds me of another great biologist, C.H. Waddington, to whom Noble pays handsome tribute. Writing with clarity and charm, Noble attempts to break down silos of knowledge inhabited by scientists who fail to come out and engage with others. Self-serving priesthoods have never been attractive. Broadening minds in an era of intense specialisation is more important than ever. Noble deserves to be successful in his desire to do just that and I hope that he will be.' Sir Patrick Bateson, University of Cambridge

    'In my view Dance to The Tune of Life is a 'must read'. In it Denis Noble lucidly deconstructs how and why reductionism came to prominence in biology and led to the current state of molecular Humpty-Dumptyism. His central idea that there is no privileged level of causation is the first conceptual step to putting Humpty Dumpty back together again.' Michael J. Joyner, Mayo Clinic, Minnesota

    'Denis Noble is renowned for his mission to reintegrate the physiological sciences with mainstream biology, including evolutionary theory. His new book combines clear exposition of basic principles with many valuable examples. He gives the reader, general or expert, a completely new view of life.' Yung E. Earm, Seoul National University, South Korea

    'Dance to the Tune of Life is one of the most fascinating and impressive books I have ever read. Denis Noble, a world-renowned physiologist and systems biologist, has revolutionized our traditional notion of the nature of life. The title Dance to the Tune of Life mirrors the essence of the argument of the book. The life emerges from numerous biological processes at different scales and levels. Such actors and actresses, stage properties, and stage are not separately present they act together in harmony, dancing to a tune with a music performed by an orchestra, an organism. By describing his research experiences and achievements on the cardiac rhythm evolutionary biology, medicine, and philosophy, Denis has not only provided us with very modern knowledge of the biological reactions and their network but also described to us the nature of life. I believe that this book impacts everyone involved in biomedicine.' Yoshihisa Kurachi, Osaka University, Japan

    'Having demolished the 'Selfish Gene' fiction, Noble in this marvelous book moves both science and philosophy from an antiquated 'either/or' static model to an 'and' model. 'Dance' shows elegantly and brilliantly that from the miracle of the ancient symbiosis of mitochondrial bacterial remnants in human cells, through the rock-solid interrelationship between genes and the feedback from the environment in all senses - from the core phenomenon of functional epigenetics, to the universe itself and our place in it - that we are, at heart, inter-beings, co-arising.' Samuel Shem, New York University

    'Denis Noble is a pioneer in understanding human physiology through quantitative studies linking behaviour across multiple scales of biological organization - from proteins to cells, tissues, organs and organ systems. These studies have led him to characterize biological function in terms of a Principle of Biological Relativity: there is no privileged level of causation in biology, because living organisms are multilevel open stochastic systems in which the behaviour at any level depends on higher and lower levels, and so cannot be fully understood in isolation. This engaging book defends this view in depth, and thereby also provides strong support for an extended synthesis of evolutionary theory that goes beyond the Modern Synthesis of Neo-Darwinism. It is highly recommended as a thoughtful study of the kind of complexity real living organisms display.' George Ellis FRS, University of Cape Town, South Africa

    'In this elegantly written and personal book world-renowned physiologist and systems biologist Denis Noble effectively argues for a fundamental revision of the theory of evolution. Against the reductionist, gene-centered approach of Neo-Darwinism, which has dominated biology for more than a century, Noble passionately pleas for a more integrated approach. Massively supported by recent postgenomic and epigenetic empirical research, Dance to the Tune of Life deepens and synthesizes ideas Noble earlier developed in The Music of Life. Biology beyond the Genome (2006) and subsequent writings. Just like Newtonian physics underwent a major transformation in the beginning of the 20th century due to Einstein's general theory of relativity, the life sciences are facing a no less fundamental transformation. Noble's book is a must read for anyone who wants to understand this transformation.' Jos de Mul, Erasmus University Rotterdam, Netherlands

    '… enlightening … The illustrations are both vibrant and clarifying, giving this title a sparkle that compels you to imagine how each concept fits into the larger scheme. I commend this author for relishing the subtle reminders of what makes this inquiry important. It's a best read.' D. Wayne Dworsky, San Francisco Book Review (www.sanfranciscobookreview.com)

    '… a very informative read … Noble's Dance to the Tune of Life is an illuminating account of why philosophy is necessary in doing science.' Sepehr Ehsani, Metascience

    See more reviews

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity

    ×

    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?

    ×

    Product details

    • Date Published: December 2016
    • format: Hardback
    • isbn: 9781107176249
    • length: 302 pages
    • dimensions: 235 x 160 x 20 mm
    • weight: 0.64kg
    • contains: 21 b/w illus. 26 colour illus.
    • availability: In stock
  • Table of Contents

    Preface
    Acknowledgments
    1. The universe and the principle of relativity
    2. Biological scales and levels
    3. Biological networks
    4. Nature and origin of cells
    5. Blind chance and natural selection
    6. Biological relativity
    7. Dancing nucleotides: natural genetic engineering
    8. Epigenetics and a relativistic theory of evolution
    9. The relativity of epistemology: the meaning of it all
    10. Postscript
    Glossary
    Index.

  • Resources for

    Dance to the Tune of Life

    Denis Noble

    General Resources

    Welcome to the resources site

    Here you will find free-of-charge online materials to accompany this book. The range of materials we provide across our academic and higher education titles are an integral part of the book package whether you are a student, instructor, researcher or professional.

    Find resources associated with this title

    Type Name Unlocked * Format Size

    Showing of

    Back to top

    *This title has one or more locked files and access is given only to lecturers adopting the textbook for their class. We need to enforce this strictly so that solutions are not made available to students. To gain access to locked resources you either need first to sign in or register for an account.


    These resources are provided free of charge by Cambridge University Press with permission of the author of the corresponding work, but are subject to copyright. You are permitted to view, print and download these resources for your own personal use only, provided any copyright lines on the resources are not removed or altered in any way. Any other use, including but not limited to distribution of the resources in modified form, or via electronic or other media, is strictly prohibited unless you have permission from the author of the corresponding work and provided you give appropriate acknowledgement of the source.

    If you are having problems accessing these resources please email lecturers@cambridge.org

  • Author

    Denis Noble, University of Oxford
    Denis Noble, CBE, FRS, is Emeritus Professor of Cardiovascular Physiology and Director of Computational Physiology at the University of Oxford. He is one of the founders of the field of systems biology and is the current President of the International Union of Physiological Sciences (IUPS).

Sign In

Please sign in to access your account

Cancel

Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email lecturers@cambridge.org

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.

Cancel

Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

×
Please fill in the required fields in your feedback submission.
×