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MicroRNAs
From Basic Science to Disease Biology

CAD$102.95 (C)

Sidney Altman, Victor R. Ambros, Krishnarao Appasani, Ines Alvarez-Garcia, Eric A. Miska, Shao-Yao Ying, Joseph D. Miller, Shi-Lung Lin, Joshua W. Hagen, Eric C. Lai, Danielle M. Maatouk, Jason R. Rock, Brian D. Harfe, Hui Zhou, Yue-Qin Chen, Yu-Chun Luo, Jia-Fu Wang, Liang-Hu Qu, David T. Humphreys, Belinda J. Westman, David I. K. Martin, Thomas Preiss, Diana K. Darnell, Stacey Stanislaw, Simran Kaur, Tatiana A. Yatskievych, Sean Davey, Jay H. Konieczka, Parker B. Antin, Gerhard Schratt, Michael Greenberg, Dean J. Danner, John Barnes, Benjamin Mersey, Ramiro E. Rodriguez, Carla Schommer, Javier Palatnik, Anton J. Enright, Sam-Griffith-Jones, Dominic Grün, Nikolaus Rajewsky, Praveen Sethupathy, Molly Megraw, Artemis G. Hatzigeorgiou, Marc Rehmsmeier, Pål Sætrom, Ola Snøve Jr., Neil R. Smalheiser, Vetle I. Torvik, Sakari Kauppinen, Hatim T. Allawi, Victor I. Lyamichev, Sonal Patel, Joanne Garver, Michael Gallo, Maria Hackett, Stephen McLaughlin, Mark Nadel, John Harris, Duncan Whitney, Lori A. Neely, Yu Liang, Linda Wong, Ruoying Tan, Caifu Chen, Gregory J. Hurteau, Simon D. Spivack, Graham J. Brock, Kathryn A. O'Donnell, Joshua T. Mendell, Muller Fabbri, Ramiro Garzon, Amelia Cimmino, George Adrian, Carlo Maria Croce, Andrea Ventura, Madhu S. Kumar, Tyler Jacks, Jinhong Chang, John M. Taylor, Silvia Anna Ciafrè, Keith Szulwach, Peng Jin, Takashi Sonoki, Norio Asou, Tomoko Kozu, Irina Naguibneva, Anna Polesskaya, Annick Harel-Bellan, Finn Grey, Alec J. Hirsch, Jay A. Nelson, Yoichi Robertus Fujii, Hristo B. Houbaviy, Michaela Scherr, Matthias Eder, Yvonne Tay, Andrew M. Thomson, Bing Lim, Fuchou Tang, Kaiqin Lao, M. Azim Surani
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  • Date Published: August 2009
  • availability: Available
  • format: Paperback
  • isbn: 9780521118552

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  • MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

    • Widest possible treatment of this cutting-edge technology, from the basic science to industry applications
    • Contributions from leading researchers in academia and industry, including a Foreword by Nobel Prize-winner, Sidney Altman, and Victor R. Ambros, the co-discoverer of MicroRNA
    • The first truly comprehensive book on this topic; serving as a resource for basic scientists and those in R&D
    Read more

    Reviews & endorsements

    "It will be a valuable reading for both students who want to gain a better understanding of alternative mechanisms of gene regulation, and scientists who intend to investigate the role of miRNAs in their research projects."
    Silvana Debernardi, The Quarterly Review of Biology

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    Product details

    • Date Published: August 2009
    • format: Paperback
    • isbn: 9780521118552
    • length: 580 pages
    • dimensions: 254 x 178 x 30 mm
    • weight: 0.99kg
    • availability: Available
  • Table of Contents

    Foreword
    Foreword
    Introduction Part I. Discovery of MicroRNAs in Various Organisms:
    1. The microRNAs of C. elegans
    2. Non-coding RNAs - development of man-made vector-based intronic microRNAs
    3. Seeing is believing: strategies for studying microRNA expression
    4. MicroRNAs in limb development
    5. Identification of miRNAs in plant oryza sativa
    Part II. MicroRNA Functions and RNAi-Mediated Pathways:
    6. Inhibition of translation initiation by a microRNA
    7. In situ analysis of microRNA expression during vertebrate development
    8. MicroRNA function in the nervous system
    9. Micro RNA expression that controls the amount of branched chain α-ketoacid dehydrogenase in mitochondria of human cells
    10. MicroRNAs and the regulation of leaf shape
    Part III. Computational Biology of MicroRNAs:
    11. MiRBase: a database of microRNA sequences, targets and nomenclature
    12. Computational prediction of microRNA targets in vertebrates, fruitflies and nematodes
    13. Computational approaches to elucidate miRNA biology
    14. The RNA hybrid approach to microRNA target prediction
    15. Machine learning predicts microRNA target sites
    16. Models of microRNA-target coordination
    Part IV. Detection and Quantitation of MicroRNAs:
    17. Detection and analysis of microRNAs using LNA (locked nucleic acid)-modified probes
    18. Detection and quantitation of microRNAs using the RNA Invader® assay
    19. A single molecule method to quantify miRNA gene expression
    20. Real-time quantification of MicroRNAs by TaqMan® assays
    21. Real-time quantification of miRNAs and mRNAs employing universal reverse transcription
    Part V. MicroRNAs in Disease Biology:
    22. Dysregulation of microRNAs in human malignancy
    23. High throughput microRNAs profiling in cancers
    24. Roles of microRNAs in cancer and development
    25. MiR-122 in mammalian liver
    26. MiRNAs in glioblastoma
    27. Role of microRNA pathway in Fragile X mental retardation
    28. Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia
    29. MiRNAs in TPA-induced differentiation of HL-60 cells
    30. MiRNAs in skeletal muscle differentiation
    31. Identification and potential function of viral microRNAs
    32. Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase
    Part VI. MicroRNAs in Stem Cell Development:
    33. MicroRNAs in the stem cells of the mouse Blastocyst
    34. The role of miRNA in hematopoiesis
    35. MicroRNAs in embryonic stem cell differentiation and prediction of their targets
    36. Generation of single cell microRNA expression profile.

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    MicroRNAs

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  • Editor

    Krishnarao Appasani

    Foreword

    Sidney Altman

    Victor R. Ambros

    Contributors

    Sidney Altman, Victor R. Ambros, Krishnarao Appasani, Ines Alvarez-Garcia, Eric A. Miska, Shao-Yao Ying, Joseph D. Miller, Shi-Lung Lin, Joshua W. Hagen, Eric C. Lai, Danielle M. Maatouk, Jason R. Rock, Brian D. Harfe, Hui Zhou, Yue-Qin Chen, Yu-Chun Luo, Jia-Fu Wang, Liang-Hu Qu, David T. Humphreys, Belinda J. Westman, David I. K. Martin, Thomas Preiss, Diana K. Darnell, Stacey Stanislaw, Simran Kaur, Tatiana A. Yatskievych, Sean Davey, Jay H. Konieczka, Parker B. Antin, Gerhard Schratt, Michael Greenberg, Dean J. Danner, John Barnes, Benjamin Mersey, Ramiro E. Rodriguez, Carla Schommer, Javier Palatnik, Anton J. Enright, Sam-Griffith-Jones, Dominic Grün, Nikolaus Rajewsky, Praveen Sethupathy, Molly Megraw, Artemis G. Hatzigeorgiou, Marc Rehmsmeier, Pål Sætrom, Ola Snøve Jr., Neil R. Smalheiser, Vetle I. Torvik, Sakari Kauppinen, Hatim T. Allawi, Victor I. Lyamichev, Sonal Patel, Joanne Garver, Michael Gallo, Maria Hackett, Stephen McLaughlin, Mark Nadel, John Harris, Duncan Whitney, Lori A. Neely, Yu Liang, Linda Wong, Ruoying Tan, Caifu Chen, Gregory J. Hurteau, Simon D. Spivack, Graham J. Brock, Kathryn A. O'Donnell, Joshua T. Mendell, Muller Fabbri, Ramiro Garzon, Amelia Cimmino, George Adrian, Carlo Maria Croce, Andrea Ventura, Madhu S. Kumar, Tyler Jacks, Jinhong Chang, John M. Taylor, Silvia Anna Ciafrè, Keith Szulwach, Peng Jin, Takashi Sonoki, Norio Asou, Tomoko Kozu, Irina Naguibneva, Anna Polesskaya, Annick Harel-Bellan, Finn Grey, Alec J. Hirsch, Jay A. Nelson, Yoichi Robertus Fujii, Hristo B. Houbaviy, Michaela Scherr, Matthias Eder, Yvonne Tay, Andrew M. Thomson, Bing Lim, Fuchou Tang, Kaiqin Lao, M. Azim Surani

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