The Placenta and Human Developmental Programming

Cambridge University Press

9780521199452 - The Placenta and Human Developmental Programming - Edited by Graham J. Burton, David J. P. Barker, Ashley Moffett and Kent Thornburg

Table of Contents

List of contributors	vii
Preface	xi
1 Introduction Graham J. Burton, David J. P. Barker, Ashley Moffett and Kent Thornburg	1
2 The maternal and placental origins of chronic disease David J. P. Barker, Johan G. Eriksson, Eero Kajantie, Saleh H. Alwasel, Caroline H. D. Fall, Tessa J. Roseboom and Clive Osmond	5
Chapter 2 Discussion	13
3 Pre- and periconceptual health and the HPA axis: nutrition and stress Alan A. Jackson, Graham Burdge and Karen Lillycrop	17
Chapter 3 Discussion	32
4 Nutrition and preimplantation development Tom P. Fleming	35
Chapter 4 Discussion	44
5 Maternofetal transport pathways during embryogenesis and organogenesis Eric Jauniaux and Graham J. Burton	47
Chapter 5 Discussion	54
6 Imprinted genes and placental growth: implications for the developmental origins of health and disease Benjamin Tycko and Rosalind John	57
Chapter 6 Discussion	71
7 Genomic imprinting: epigenetic control and potential roles in the developmental origins of postnatal health and disease Elizabeth J. Radford and Anne C. Ferguson-Smith	74
Chapter 7 Discussion	91
8 Trophoblast invasion and uterine artery remodelling in primates Robert Pijnenborg, Lisbeth Vercruysse and Anthony M. Carter	92
Chapter 8 Discussion	98
9 The role of the maternal immune response in fetal programming Ashley Moffett	102
Chapter 9 Discussion	111
10 Clinical causes and aspects of placental insufficiency Irene Cetin and Emanuela Taricco	114
Chapter 10 Discussion	123
11 Uterine blood flow as a determinant of fetoplacental development Lorna G. Moore	126
Chapter 11 Discussion	144
12 Placental amino acid transporters: the critical link between maternal nutrition and fetal programming? Thomas Jansson and Theresa L. Powell	147
Chapter 12 Discussion	158
13 The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress Graham J. Burton and Eric Jauniaux	161
Chapter 13 Discussion	171
14 Glucocorticoids and placental programming Owen R. Vaughan, Alison J. Forhead and Abigail L. Fowden	175
Chapter 14 Discussion	186
15 Clinical biomarkers of placental development Gordon C. S. Smith	188
Chapter 15 Discussion	198
16 The placental roots of cardiovascular disease Kent Thornburg, Perrie F. O'Tierney, Terry Morgan and Samantha Louey	201
Chapter 16 Discussion	214
17 Placental function and later risk of osteoporosis Cyrus Cooper, Laura Goodfellow, Nicholas Harvey, Susie Earl, Christopher Holroyd, Zoe Cole and Elaine Dennison	216
Chapter 17 Discussion	227
18 Final general discussion	229
19 The placenta and developmental programming: some reflections Robert Boyd and Richard Boyd	233
Index	236

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Library of Congress

The Placenta and Human Developmental Programming

Edited by Graham J. Burton

Department of Anatomy, University of Cambridge

David J. P. Barker

MRC Epidemiology Resource Centre, University of Southampton

Ashley Moffett

Department of Pathology, University of Cambridge

Kent Thornburg

Department of Obstetrics and Gynecology, Oregon Health and Sciences University, Portland, OR

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