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Secondary Schizophrenia


  • 23 b/w illus. 2 colour illus. 35 tables
  • Page extent: 450 pages
  • Size: 246 x 189 mm
  • Weight: 1.11 kg


 (ISBN-13: 9780521856973)

Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.

• Comprehensive coverage of medical conditions that can present as schizophrenia-like psychosis • Reviews in depth the facets of association of medical conditions and psychosis, providing a ready source for trainees and specialists • Describes potential mechanisms for the associations, useful for researchers looking to understand the pathogenesis of schizophrenia


Part I. Introduction: 1. The neurobiology and aetiology of primary schizophrenia: current status Matcheri S. Keshavan and Ripu D. Jindal; 2. The concept of organicity and its application to schizophrenia Perminder S. Sachdev; 3. Secondary hallucinations Mark Walterfang, Ramon Mocellin, David Copolov and Dennis Velakoulis; Part II. The Neurology of Schizophrenia: 4. The neurologic examination in schizophrenia Richard D. Sanders and Matcheri S. Keshavan; 5. Functional neuroimaging in schizophrenia Serge A. Mitelman, Jane Zhang and Monte S. Buchsbaum; Part III. Organic Syndromes of Schizophrenia; Section 1. Epilepsy and Schizophrenia: 6. Schizophrenia-like psychosis and epilepsy Perminder S. Sachdev; 7. Understanding the pathophysiology of schizophrenia through the looking glass of forced normalization Ennapadam S. Krishnamoorthy and Seethalakshmi Ramanathan; Section 2. Drugs and Schizophrenia-like Psychosis: 8. Substance-induced psychosis: an overview Jagadisha Thirthalli, Vivek Benegal and Bangalore N. Gangadhar; 9. Stimulants and psychosis Nash N. Boutros, Matt Galloway and Eric M. Pihlgren; 10. The psychotomimetic effects of PCP, LSD and Ecstasy: pharmacological models of schizophrenia? Vibeke S. Catts and Stanley V. Catts; 11. Schizophrenia secondary to cannabis use Wayne Hall and Louisa Degenhardt; 12. Toxic psychosis Rajeev Kumar and Jeffrey C. L. Looi; Section 3. Other Neurological Disorders: 13. Schizophrenia-like psychosis and traumatic brain injury (TBI) Perminder S. Sachdev; 14. Cerebrovascular disease and psychosis Osvaldo P. Almeida and Sergio E. Starkstein; 15. Neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia) and schizophrenia-like psychosis Nicola T. Lautenschlager and Alexander F. Kurz; 16. Storage disorders and psychosis Mark Walterfang and Dennis Velakoulis; 17. Mitochondrial disorders and psychosis Dennis Velakoulis and Mark Walterfang; 18. Psychosis associated with leukodystrophies Patricia I. Rosebush, Rebecca Anglin and Michael Mazurek; 19. Normal pressure hydrocephalus Julian Trollor; 20. Brain tumours Malcolm Hopwood and Lyn-May Lim; 21. Demyelinating disease and psychosis Anthony Feinstein; Section 4. Systemic Disorders: 22. Infection and schizophrenia Alan S. Brown and Ezra S. Susser; Section 5. Genetic Disorders Related to SLP: 23. The status of genetic investigations of schizophrenia Bryan Mowry; 24. Velocardiofacial Syndrome (Chromosome 22q11.2 Deletion Syndrome) as a model of schizophrenia Vandana Shashi and Margaret N. Berry; 25. Psychosis in Prader-Willi Syndrome Stewart L. Einfeld, Sophie Kavanagh, Arabella Smith and Bruce J. Tonge; 26. Friedrich's Ataxia and schizophrenia-type psychosis Perminder S. Sachdev; 27. Wilson's disease Edward C. Lauterbach and Leslie Lester-Burns; 28. Huntington's disease and related disorders and their association with schizophrenia-like psychosis Perminder S. Sachdev; 29. Fahr's disease and psychosis Kim Burns and Henry Brodaty; Part IV. Related Concepts: 30. The Charles Bonnet Syndrome William Burke; 31. Acute brief psychosis – an organic syndrome? Anand K. Pandurangi; Part V. Treatment: 32. Drug treatment of secondary schizophrenia Michael D. Jibson and Rajiv Tandon; 33. Non-pharmacological interventions in secondary schizophrenia David J. Kavanagh, Jennifer M. Connolly and Kim T. Mueser.


' … this book provides a rich and comprehensive review of the many conditions know n to be associated with psychosis, which could be of great value to students and a resource for senior scientists in the field. it is thought-provoking and its treatments of provocative issues resulting from very recent research are timely and enjoyable. The book is particularly satisfying because it excels on so many levels. This includes the clear list-making organization of basic facts characteristic of the allopathic tradition, and the thoughtful attempt at integration of disparate findings into etiopathogenic explanations of signs and symptoms. Adding to this already very useful review of vast swathes of clinically oriented literature is the valiant and nuanced contextualization of otherwise typical textbook fare into the fundamental conceptual conundrm lurking at the heart of the entire book: what is schizophrenia.' The Journal of Psychological Medicine


Matcheri S. Keshavan, Ripu D. Jindal, Perminder S. Sachdev, Mark Walterfang, Ramon Mocellin, David Copolov, Dennis Velakoulis, Richard D. Sanders, Serge A. Mitelman, Jane Zhang, Monte S. Buchsbaum, Ennapadam S. Krishnamoorthy, Seethalakshmi Ramanathan, Jagadisha Thirthalli, Vivek Benegal, Bangalore N. Gangadhar, Nash N. Boutros, Matt Galloway, Eric M. Pihlgren, Vibeke S. Catts, Stanley V. Catts, Wayne Hall, Louisa Degenhardt, Rajeev Kumar, Jeffrey C. L. Looi, Osvaldo P. Almeida, Sergio E. Starkstein, Nicola T. Lautenschlager, Alexander F. Kurz, Patricia I. Rosebush, Rebecca Anglin, Michael Mazurek, Julian Trollor, Malcolm Hopwood, Lyn-May Lim, Anthony Feinstein, Alan S. Brown, Ezra S. Susser, Bryan Mowry, Vandana Shashi, Margaret N. Berry, Stewart L. Einfeld, Sophie Kavanagh, Arabella Smith, Bruce J. Tonge, Edward C. Lauterbach, Leslie Lester-Burns, Kim Burns, Henry Brodaty, William Burke, Anand K. Pandurangi, Michael D. Jibson, Rajiv Tandon, David J. Kavanagh, Jennifer M. Connolly, Kim T. Mueser

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