Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-06-12T01:20:42.638Z Has data issue: false hasContentIssue false
  • English
  • Français

Chronon and the Problem of Anticipation (On two family cases of diabetes)

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
D. Casa  and
G. Brenci
L. Gedda
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma
D. Casa
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The Authors analyze the phenomenon whereby, in progressing from generation to generation, a hereditary disease may appear at an earlier, equal or later age (anticipation, repetition or posticipation, respectively). They believe that this represents the phenotypic effect of a temporal dimension of the gene, the “chronon”, which may reveal stability, plus-variance or minus-variance according to the standard genetic models. This interpretation provides an explanation of two family cases of diabetes mellitus, respectively exhibiting anticipation and posticipation, and repetition.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 16 , Issue 3 , July 1967 , pp. 217 - 228
Copyright
Copyright © The International Society for Twin Studies 1967

References

Literature

Barrai, I., Cann, H. M. (1965). Transmission of diabetes mellitus. J. Med. Genet., II, 8: 11.Google Scholar
Bartalos, M. (1967). On the concepts of chronon and chronaxy and their implications in neoplasia. A.Ge.Me.Ge., 16: 1.Google Scholar
Gedda, L. (1961). Genetica clinica. Proceed. IInd Internat. Congr. Hum Genet., II, Ed. Ist. Mendel, Rome, 1963.Google Scholar
Gedda, L. (1965 a). Application de la génétique à la pratique médicale (La constitution au point de vue de la génétique – Le “chronon”: concept et application au service de la médecine). A.Ge.Me.Ge., 14: 1.Google Scholar
Gedda, L. (1965 b). From Gregor Mendel to medical genetics. A.Ge.Me.Ge., 14: 3.Google Scholar
Gedda, L. (1965 c). Da Mendel alla genetica clinica. In: Così cominciò la Genetica. Ed. A.Ge.Me.Ge., Roma, 1967.Google Scholar
Gedda, L. (1967). Concetti e problemi della genetica medica. A.Ge.Me.Ge., 16: 2.Google Scholar
Gedda, L., Brenci, G. (1966). Chronological aspects of gene action: a twin study. A.Ge.Me.Ge., 15: 4.Google Scholar
Gedda, L. et al. (1966 a). La predisposizione genetica nella malattia tubercolare (Studio su 447 coppie di fratelli ammalati). A.Ge.Me.Ge., 15: 1.Google Scholar
Gedda, L. et al. (1966 b). Malattie, malformazioni e malposizioni dentarie studiate con il test clinico-gemellare. A.Ge.Me.Ge., 15: 2.Google Scholar
Hanhart, E., Fraccaro, M. (1954). Genetical analysis of 995 cases of diabetes mellitus. Caryologia, 6: 1052 (Suppl.).Google Scholar
Marble, A. (1967). Definition and criteria for the prediabetic state. Panel discussion. 6th Congress of the Internat. Diabetes Feder., Stokholm.Google Scholar
Neel, J. V. et al. (1965). Diabetes mellitus. In: Genetics and the Epidemiology of Chronic Diseases. U. S. Dept. of Health, Education and Welfare, Washington.Google Scholar
Jörgensen, G. (1966). Zur Genetik des idiopathischen Diabetes mellitus. Deutsch. Med. J., 17: 13.Google ScholarPubMed
Parisi, P., Di Bacco, M. (1967). Le impronte digitali nei gemelli (Analisi quali-quantitativa). A.Ge.Me.Ge., 16: 1.Google Scholar
Penrose, L. S. (1948). The problem of anticipation in pedigrees of dystrophia myotonica. Ann. Eugen., 14: 125–132.CrossRefGoogle ScholarPubMed
Smith, S. M. et al. (1961). Mathematical Tables for Research Workers in Human Genetics. Churchill, London.Google Scholar
Steinberg, A. G. (1959). The genetics of diabetes: a review. Ann. New York Acad. Sci.. 82: 2.Google Scholar
Steinberg, A. G., Wilder, R. M. (1952). An analysis of the phenomenon of “anticipation” in diabetes mellitus. Ann. Intern. Med., 36: 1285.Google Scholar
Stern, C. (1960). Human Genetics. W. H. Freeman & Co., 2nd Ed., San Francisco and London.Google Scholar
World Health Organization (1966). The use of twins in epidemiological studies. A.Ge.Me.Ge., 16: 2.Google Scholar