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Glomerular Filtration Rate and Electrolyte Handling in Response to Sodium Loading and Depletion. A Twin Study

Published online by Cambridge University Press:  01 August 2014

C.E. Grim ,
Judy Z. Miller  and
Joe C. Christian
C.E. Grim*
Affiliation:
Departments of Medicine and Medical Genetics, Indiana University School of Medicine, Indianapolis
Judy Z. Miller
Affiliation:
Departments of Medicine and Medical Genetics, Indiana University School of Medicine, Indianapolis
Joe C. Christian
Affiliation:
Departments of Medicine and Medical Genetics, Indiana University School of Medicine, Indianapolis
*
Specialized Center of Research (SCOR) in Hypertension, Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, IN 46202

Abstract

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Possible genetic influences on glomerular filtration rate and electrolyte excretion were investigated in 55 (37 monozygotic, 18 dizygotic) young adult white twin pairs. Subjects were studied during a five-day hospitalization involving sodium loading and sodium depletion. No evidence of genetic variability was found in the control levels of serum or urine sodium and potassium. Following a saline infusion it was possible to detect genetic influence in electrolyte handling. Creatinine clearance, used as a measure of glomerular filtration rate, did not appear to be genetically mediated. The results indicate that genetic factors are important in sodium handling in normal individuals and that this is independent of glomerular filtration rate.

Keywords

Blood pressureGlomerular filtrationElectrolyte excretionSodium handlingGenetic factorsTwin study
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 28 , Issue 2 , April 1979 , pp. 149 - 154
Copyright
Copyright © The International Society for Twin Studies 1979

References

REFERENCES

1.Bianchi, G, Baer, PG, Fox, U, Duzzi, L, Pgetti, D, Giovannetti, AM (1975): Changes in renin, water balance, and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res (Suppl 1) Vol 36–37, pp 1–153, 1–161.Google Scholar
2.Borhani, NO, Feinleib, M, Garrison, RJ, Christian, JC, Rosenman, RH 1976: Genetic variance in blood pressure. Acta Genet Med Gemellol 25:137–144.Google Scholar
3.Christian, JC, Kang, KW, Norton, JA Jr 1974: Choice of an estimate of genetic variance from twin data. Am J Hum Genet 26:154–161.Google Scholar
4.Christian, JC, Feinleib, M, Norton, JA Jr (1975): Statistical analysis of genetic variance in twins. Am J Hum Genet 27:807.Google Scholar
5.Christian, JC, Norton, JA Jr 1977: A proposed test of the differences between the means of monozygotic and dizygotic twins. Acta Genet Med Gemellol 26:49–54.CrossRefGoogle ScholarPubMed
6.Christian, JC 1979: Testing twin means and estimating genetic variance. Basic methodology for the analysis of quantitative twin data. Acta Genet Med Gemellol 28:35–40.Google ScholarPubMed
7.Dahl, LK, Knudsen, KD, Heine, MA, Leitl, GJ (1968): Modification of experimental hypertension in the rat by variations in the diet. Circ Res 22:11–18, 1968.CrossRefGoogle ScholarPubMed
8.Dahl, LK, Heine, M, Thompson, K, 1972: Genetic influence of renal homografts on the blood pressure of rats from different strains. Proc Soc Exp Biol Med 140:852–856.CrossRefGoogle ScholarPubMed
9.Elston, RC, Boklage, CE (1977): An examination of the fundamental assumptions of the twin method. In Back, Net al (eds): “Progress in Clinical and Biological Research: Twin Research. Part A: Psychology and Methodology.” New York: Alan R. Liss, pp 189–199.Google Scholar
10.Grim, CE, Weinberger, MH, Higgins, JT, Kramer, NJ 1977: Diagnosis of secondary forms of hypertension. JAMA 237:1331–1335.Google Scholar
11.Grim, CE, Weinberger, MH, Henry, DP, Luft, FL, Fineberg, NS 1978: Biochemical correlates of the increase in blood pressure with age. Clin Sci Mol Med 55:377–379.Google Scholar
12.Haseman, JK, Elston, RC 1970: The estimate of genetic variance from twin data. Behav Genet 1:11–19.Google Scholar
13.McIlhany, ML, Shaffer, JW, Hines, EA 1975: The heritability of blood pressure: An investigation of 200 pairs of twins using the cold pressor test. Johns Hopkins Med J 136:57–64.Google ScholarPubMed
14.Miall, WE, Oldham, PD (1963): The hereditary factor in arterial blood pressure. Br Med J 1:75–80.Google Scholar
15.Page, LB, Damon, A, Moellering, RC 1974: Antecedent of cardiovascular disease in six Solomon Island societies. Circulation 49:1132–1146.CrossRefGoogle Scholar
16.Rose, RJ, Miller, JZ, Grim, CE, Christian, JC (In press): Aggregation of blood pressure in the families of identical twins. Am J Epidemiol.Google Scholar
17.Zinner, SH, Levy, PS, Kass, EH 1971: Familial aggregation of blood pressure in childhood. N Engl J Med 284:401–404.Google Scholar
18.Zinner, SH, Martin, LF, Sacls, F, Rosner, B, Kass, EH 1975: A longitudinal study of blood pressure in childhood. Am J Epidemiol 100:437–442.Google Scholar