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Monozygotic Twin Resemblance in Fatness and Fat Cell Lipolysis

Published online by Cambridge University Press:  01 August 2014

J.P. Després  and
C. Bouchard
J.P. Després
Affiliation:
Physical Activity Sciences Laboratory, Laval University, Quebec
C. Bouchard*
Affiliation:
Physical Activity Sciences Laboratory, Laval University, Quebec
*
Physical Activity Science Laboratory, PEPS, Laval University, Ste Foy, Quebec, CanadaGIK 7P4

Abstract

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Six skinfold measurements, and percent body fat and fat-free weight derived from the underwater weighing technique were obtained in 43 pairs of male and 44 pairs of female monozygotic (MZ) twins. A fat tissue biopsy was performed in the suprailiac region in 20 male and 16 female pairs in order to determine mean adipocyte diameter and basal lipolysis as well as epinephrine maximally stimulated lipolysis (10−4 M). Twin resemblance in body fatness is clearly demonstrated by the analysis of the between MZ sibships over the within MZ shibship means of squares for all skinfold measurements, percent body fat and fat free weight (P < 0.01). Within MZ pair similarity is as high in female as in male pairs for body fatness. Moreover, members of the same twin pair resemble one another significantly for fat cell size and fat cell lipolytic activities, particularly when epinephrine stimulated. In female MZ pairs, additional studies with control over the menstrual cycle are needed to clarify the case of isolated fat cell basal lipolysis.

Keywords

Body fatSex differencesTwinsAdipocyte diameterFat cell lipolysis
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 3 , July 1984 , pp. 475 - 480
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1.Bouchard, C 1980: Transient environmental effects detected in sibling correlations. Ann Hum Biol 7:89–92.CrossRefGoogle ScholarPubMed
2.Bouchard, C, Demirjian, A, Malina, RM 1980: Heritability estimates of somatotype components based upon familial data. Hum Hered 30:112–118.CrossRefGoogle ScholarPubMed
3.Brook, CGD, Huntley, RMC, Slack, J 1975: Influence of heredity and environment in determination of skinfold thickness in children. Brit Med J 2:719–721.CrossRefGoogle ScholarPubMed
4.Bukowiecki, L, Lupien, J, Follea, N, Paradis, A, Richard, D, Leblanc, J 1980: Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats. Am J Physiol 239:422–429.Google Scholar
5.Després, JP, Bouchard, C, Bukowiecki, L, Savard, R, Lupien, J 1983: Morphology and metabolism of human fat cells: a reliability study. Int J Obesity 7:231–240.Google ScholarPubMed
6.Garn, SM, Clark, DC, Guire, KE (1975): Growth, body composition, and development of obese and lean children. In Winick, M (ed): Childhood Obesity. New York: Wiley, p 23–46.Google Scholar
7.Haggard, EA (1958): Intraclass Correlation and the Analysis of Variance. New York: The Dryden Press.Google Scholar
8.Hamosh, M, Hamosh, P 1975: The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue. J Clin Invest 55:1132–1135.Google Scholar
9.Hansen, FM, Fahmy, N, Nielsen, JA 1980: The influence of sexual hormones on Upogenesis and lipolysis in rat fat cells. Acta Endocrinol 95:566–570.Google ScholarPubMed
10.Hawk, LJ, Brook, CGD 1979: Family resemblances of height, weight, and body fatness. Arch Dis Child 54:877–879.Google Scholar
11.Howells, WW 1966: Variability in family lines versus population variability. Ann NY Acad Sci 134:624–631.CrossRefGoogle Scholar
12.Kim, HJ, Kalkhoff, RK (1975): Sex steroid influence on triglyceride metabolism. J Clin Invest 56: 888–896.CrossRefGoogle ScholarPubMed
13.Lowry, O, Passonneau, J (1982): A Flexibile System of Enzymatic Analysis. New York: Academic Press.Google Scholar
14.Mueller, WH 1978: Transient environmental changes and age-limited genes as causes of variation in sib-sib and parent-offspring correlations. Ann Hum Biol 4:1–15.CrossRefGoogle Scholar
15.Mueller, WH, Malina, RM (1980): Genetic and environmental influences on growth of Philadelphia Black and White schoolchildren. Ann Hum Biol 7:441–448.CrossRefGoogle ScholarPubMed
16.Osborne, RH, DeGeorge, FV (1959): Genetic Basis of Morphological Variation. Cambridge: Harvard University Press.Google Scholar
17.Ritthaler, F, Weiss, M, Hack, F, Weicker, H (1980): Two biopsy techniques for human subcutaneous adipose tissue. Int J Sports Med 1:50–51.CrossRefGoogle Scholar
18.Rodbell, M 1964: Metabolism of isolated fat cells. J Biol Chem 239:375–380.CrossRefGoogle ScholarPubMed
19.Savard, R, Bouchard, C, Leblanc, C, Tremblay, A (1983): Familial resemblance in fatness indicators. Ann Hum Biol 10:111–118CrossRefGoogle ScholarPubMed
20.Siri, WE 1956: The gross composition of the body. Adv Biol Med Phys 4:239–280.Google Scholar
21.Snedecor, GW, Cochran, WG (1967): Statistical Methods. Ames: Iowa State University Press.Google Scholar
22.Wade, GN, Gray, JM (1979): Gonadal effects on food intake and adiposity: a metabolic hypothesis. Physiol Behav 22:583–593Google Scholar
23.Weiner, JS, Lourie, JA (1969): Human Biology, A Guide to Field Methods. Oxford: Blackwell Scientific Publ.Google Scholar
24.Wilmore, JHVodak, PA, Parr, RB, Girandola, RN, Billing, JE 1980: Further simplification of a method for determination of residual lung volume. Med Sci Sports Exercise 12:216–218.Google Scholar
25.Winer, BJ (1971): Statistical Principles in Experimental Design. New York: McGraw-Hill.Google Scholar