Hostname: page-component-848d4c4894-p2v8j Total loading time: 0 Render date: 2024-06-10T20:50:26.360Z Has data issue: false hasContentIssue false
  • English
  • Français

Screening for Multiple Pregnancy Determination of Human Chorionic Gonadotropin (hCG), Alpha-Fetoprotein (α-FP) and Human Placental Lactogen (hPL) in Blood During the Second Trimester of Pregnancy

Published online by Cambridge University Press:  01 August 2014

F. Vandekerckhove ,
M. Dhont ,
M. Thiery  and
R. Derom
F. Vandekerckhove*
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
M. Dhont
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
M. Thiery
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
R. Derom
Affiliation:
Department of Obstetrics and Gynecology, University of Gent, Belgium
*
Department of Obstetrics and Gynecology, De Pintelaan 185, 9000 Gent, Belgium

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The value of single determinations of serum hCG, hPL, and αFP for the detection of multiple pregnancy was investigated in a consecutive series of 992 women between the 14th and 24th week of pregnancy. With the 90th percentile as referent value, all twin pregnancies (n = 10) were detected by the combined results of the three determinations. Considered separately, hPL proved to be the most useful indicator of multiple gestation; the sensitivity of hPL alone was 70% and the predictive value of hPL concentrations above the 90th percentile was 8.1.

Keywords

Chorionic gonadotropinAlpha-fetoproteinHuman placental lactogenTwin pregnancy
Type
Short Note
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 4 , October 1984 , pp. 571 - 574
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1. Dhont, M, Thiery, M, Vandekerckhove, D (1976): Hormonal screening for detection of twin pregnancies (letter), Lancet 2:861.CrossRefGoogle Scholar
2. Grennert, I, Persson, PH, Gennser, G et al (1976): Ultrasound and hPL screening for early detection of twin pregnancies. Lancet 1:4–6.10.1016/S0140-6736(76)92905-6CrossRefGoogle ScholarPubMed
3. Jovanovic, L, Landesman, R, Saxena, BB (1977): Screening for twin pregnancy. Science 198: 738.CrossRefGoogle ScholarPubMed
4. Keilani, Z, Clarke, PC, Kitau, MJ, Chard, T (1978): The significance of raised maternal plasma alpha-fetoprotein in twin pregnancy. Br J Obstet Gynecol 85:510.CrossRefGoogle ScholarPubMed
5. Mägiste, M, von Schenck, H, Sjöberg, NO, Thorell, JI, Aberg, A (1976): Screening for detecting twin pregnancy. Am J Obstet Gynecol 126:697.10.1016/0002-9378(76)90522-6CrossRefGoogle ScholarPubMed
6. Thiery, M, Dhont, M, Vandekerckhove, D (1976): Serum hCG and hPL in twin pregnancies. Acta Obstet Gynecol Scand 56:495–497.CrossRefGoogle Scholar
7. Thomas, K, Ferin, J (1968): New rapid radioimmunoassay for hCG (LH, ICSH) in plasma using dioxan. J Am Endocrinol Metabol 28:1667.10.1210/jcem-28-11-1667CrossRefGoogle ScholarPubMed
8. Wald, N, Barker, S, Peto, R, Broeck, OJH, Bonnar, J (1975): Maternal serum alpha-fetoprotein levels in multiple pregnancy. Br Med J 1:961.CrossRefGoogle ScholarPubMed