Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-06-12T08:07:22.790Z Has data issue: false hasContentIssue false
  • English
  • Français

Study of Mouse Hemoglobin by Starch-Gel Electrophoresis*

Published online by Cambridge University Press:  01 August 2014

T. N. Mehrotra  and
Giuseppe Cardinali
T. N. Mehrotra
Affiliation:
Lab. of Experimental Hematology, The Children's Cancer Research Foundation and Dept. of Pathology, Harvard Medical School, The Children's Hospital, Boston, Mass. (U.S.A.)
Giuseppe Cardinali
Affiliation:
Lab. of Experimental Hematology, The Children's Cancer Research Foundation and Dept. of Pathology, Harvard Medical School, The Children's Hospital, Boston, Mass. (U.S.A.)

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The hemoglobin pattern of 18 inbred strains of mice was studied by starch-gel electrophoresis. In 7 strains (C57BL/10, C57BL/6, C57BR/cd, C57L, C58, SWR, and SEC/1Re) the electrophoretic pattern was found to be of single-band type: in the remaining 11 strains (AKR, DBA/1, DBA/2, CBA, C3H/He, C3HeB/Fe, Fl/1Re, RF, 129, A, and A/He), 6 components were constantly observed when the electrophoretic run was carried out for 20 hours. Hemoglobin from late C57BL/6 fetuses showed an electrophoretic pattern identical to that of the adult animal. Hemoglobin from AKR and DBA/2 late fetuses and newborns showed an electrophoretic pattern similar to that of the adult animal, but the slowest band was more intensely stained as compared with the corresponding band of the adult animal.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 13 , Issue 2 , April 1964 , pp. 185 - 189
Copyright
Copyright © The International Society for Twin Studies 1964

Footnotes

*

This investigation was supported in part by a research grant from the National Cancer Institute, National Institutes of Health, U. S. Public Health Service, #C-6516.

Preliminary results were presented at the Meeting of the American Society for Experimental Pathology Atlantic City N. J. April 1963 (Fed. Proc. 22: 601, 1963).

References

1. Ranney, H. M. and Gluecksohn-Waelsch, S.: Ann. Human Genet., 19: 260, 1955.Google Scholar
2. Russell, E. S. and Gerald, P. S.: Science, 128: 1569, 1958.Google Scholar
3. Rosa, J., Schapira, G., Dreyfus, J. C., De Grouchy, J., Mathe, J. and Bernard, J.: Nature, 182: 947, 1958.Google Scholar
4. Morton, J. R.: Nature, 194: 383, 1962.Google Scholar
5. Hutton, J. J., Bishop, J., Schweet, R. and Russell, E. S.: Proc. Nat. Acad. Sci., 48: 1505, 1962.Google Scholar
6. Barrowman, J. and Roberts, K. B.: Nature, 189: 409, 1961.CrossRefGoogle Scholar
7. Barrowman, J. and Craig, M.: Nature, 190: 818, 1961.Google Scholar
8. Craig, M. L. and Russell, E. S.: Fed. Proc., 22: 597, 1963.Google Scholar
9. Smith, I.: Chromatographic and electrophoretic techniques, v2, Interscience Publishers, Inc., New York, 1959.Google Scholar
10. Smithies, O.: in Advances in protein chemistry, v14, Academic Press, Inc., New York, 1959.Google Scholar
11. Mehrotra, T. N. and Cardinali, G.: Fed. Proc., 22: 601, 1963.Google Scholar