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Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: a randomised controlled clinical trial

Published online by Cambridge University Press:  05 September 2022

Elnaz Vaghef-Mehrabani Open the ORCID record for Elnaz Vaghef-Mehrabani [Opens in a new window] ,
Roya Harouni ,
Maryam Behrooz ,
Fatemeh Ranjbar ,
Mohammad Asghari-Jafarabadi  and
Mehrangiz Ebrahimi-Mameghani Open the ORCID record for Mehrangiz Ebrahimi-Mameghani [Opens in a new window]
Elnaz Vaghef-Mehrabani
Affiliation:
Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada Department of Pediatrics, University of Calgary, Calgary, AB, Canada Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Roya Harouni
Affiliation:
Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Maryam Behrooz
Affiliation:
Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Fatemeh Ranjbar
Affiliation:
Research Center of Psychiatry & Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Asghari-Jafarabadi
Affiliation:
Cabrini Research, Cabrini Health, VIC 3144, Australia School of Public Health and Preventative Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, VIC 3800, Australia Road Traffic Injury Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
Mehrangiz Ebrahimi-Mameghani*
Affiliation:
Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
*
*Corresponding author: Mehrangiz Ebrahimi-Mameghani, email ebrahimimamagani@tbzmed.ac.ir
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Abstract

Major depressive disorder (MDD) is regarded as an inflammatory disorder. Gut microbiota dysbiosis, observed in both MDD and obesity, leads to endotoxemia and inflammatory status, eventually exacerbating depressive symptoms. Manipulation of gut microbiota by prebiotics might help alleviate depression. The present study aimed to investigate the effects of inulin supplementation on psychological outcomes and biomarkers of gut permeability, endotoxemia, inflammation, and brain-derived neurotrophic factor (BDNF) in women with obesity and depression on a calorie-restricted diet. In a double-blind randomised clinical trial, forty-five women with obesity and MDD were allocated to receive 10 g/d of either inulin or maltodextrin for 8 weeks; all the patients followed a healthy calorie restricted diet as well. Anthropometric measures, dietary intakes, depression, and serum levels of zonulin, lipopolysaccharide (LPS), inflammatory biomarkers (TNF-α, IL-10, monocyte chemoattractant protein-1, toll-like receptor-4 and high-sensitivity C-reactive protein), and BDNF were assessed at baseline and end of the study. Weight and Hamilton Depression Rating Scale (HDRS) scores decreased in both groups; between-group differences were non-significant by the end of study (P = 0·333 for body weight and P = 0·500 for HDRS). No between-group differences were observed for the other psychological outcomes and serum biomarkers (P > 0·05). In this short-term study, prebiotic supplementation had no significant beneficial effects on depressive symptoms, gut permeability, or inflammatory biomarkers in women with obesity and depression.

Keywords

Calorie restrictionInflammationInulinMajor depressive disorderObesity
Type
Research Article
Information
British Journal of Nutrition , Volume 129 , Issue 11 , 14 June 2023 , pp. 1897 - 1907
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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