Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-05-30T09:17:58.528Z Has data issue: false hasContentIssue false
  • English
  • Français

Intussusception in the Syrian Golden hamster

Published online by Cambridge University Press:  09 March 2007

Stephen C. Cunnane  and
Stephen R. Bloom
Stephen C. Cunnane
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Stephen R. Bloom
Affiliation:
Royal Postgraduate Medical School, Hammersmith Hospital, DuCane Road, London W12 OHS
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production. Plasma levels of gastric inhibitory polypeptide (GIP) were reduced 80% (P < 0.01) but peptide tyrosine/tyrosine and enteroglucagon in plasma were increased 290 and 526 % respectively in hamsters with intussusception. Variations in dietary fatty acid composition had no effect but intussusception was not observed after changing the dietary carbohydrate from sucrose to starch.

Colon: Cystic fibrosis: Intussusception: Peptide hormones: Hamster

Keywords

ColonCystic fibrosisIntussusceptionPeptide hormonesHamster
Type
Digestion, Absorption and Gut Physiology
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 231 - 237
Copyright
Copyright © The Nutrition Society 1990

References

Adrian, T. E., McKeirnan, J., Johnstone, D. I., Hiller, E. J., Vyes, H., Sarson, D. L. & Bloom, S. R. (1980). Hormonal abnormalities of the pancreas and gut in cystic fibrosis. Gastroenterology 79, 460–465CrossRefGoogle ScholarPubMed
Allen, J., Penketh, A. R. L., Adrian, T. E., Lee, Y. C., Sarson, D. L., Hodson, M. E., Batten, J. C. & Bloom, S. R. (1983). Adult cystic fibrosis: postprandial response of gut regulatory peptides. Gastroenterology 85, 1379–1383.CrossRefGoogle ScholarPubMed
American Institute of Nutrition (1977). Report of the AIN ad hoc committee on standards for nutrition studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Anon (1985). Acute intussusception in children. Lancet ii, 250–251.Google Scholar
Bloom, S. R. (1972). An enteroglucagon tumor. Gut 13, 520–523.CrossRefGoogle Scholar
Bloom, S. R. & Polak, J. M. [editors] (1981). Hormone profiles. In Gut Hormones, pp. 555–560. Edinburgh: Churchill Livingstone.Google Scholar
Bryant, B. G., Bloom, S. R., Polak, J. M., Hobbs, S., Domschke, W., Domochke, S., Mitznegg, H., Ruppin, H. & Demling, L. (1983). Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine. Gut 24, 114–119.CrossRefGoogle ScholarPubMed
Jacoby, R. O. (1985). Transmissal ileal hyperplasia, hamster. In Digestive System, pp. 346–355 [Jones, T. C., Mohr, U. and Hunt, R. D.]. New York: Springer-Verlag.CrossRefGoogle Scholar
Handler, A. H. & Chesterman, F. C. (1968). Spontaneous disease. In The Golden Hamster: Its Biology and Use in Medical Research, pp. 209–214 [Hoffman, R. A., Robinson, P. F. and Magalhaes, H., editors]. Ames, Iowa: Iowa State University Press.Google Scholar
Miazza, B. M., Al-Mukhtar Salmeron, M., Ghatei, M. A., Felce-Dachez, M., Filali, A., Villet, R., Wright, N. A., Bloom, S. R. & Crambaud, J. P. (1985). Hyperenteroglucagonemia and small intestine mucosal growth after colonic perfusion of glucose in rats. Gut 26, 518–524.CrossRefGoogle Scholar
Park, R. W. & Grand, R. J. (1981). Gastrointestinal manifestations of cystic fibrosis – a review. Gastroenterology 81, 1143–1161.CrossRefGoogle ScholarPubMed
Spiller, R. C., Lee, Y. C., Edge, C., Ralphs, D. N. L., Bloom, S. R., Stewart, J. C. & Silk, D. B. A. (1984). Functional significance of the ileal break in celiac disease. Gut 25, A545.Google Scholar
Strang, R. (1959). Intussusception in infancy and childhood - a review. British Journal of Surgery 46, 484–495.CrossRefGoogle ScholarPubMed
Weaver, A. D. (1985). Canine intestinal intussusception. In Animal Models for Intestinal Disease, pp. 205–214 [Pfeiffer, C. J., editor]. Boca Raton: CRC Press.Google Scholar