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A proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat

Published online by Cambridge University Press:  09 March 2007

Hilary J. Powers ,
Lawrence T. Weaver ,
Steven Austin  and
John K. Beresford
Hilary J. Powers
Affiliation:
University Department of Paediatrics, The Stephenson Unit, Sheffield Children's Hospital, Western Bank, Sheffield S1O 2TH
Lawrence T. Weaver
Affiliation:
Medical Research Council, Dunn Nutritional Laboratory, Downhams Lane, Milton Road, Cambridge CB4 lXJ
Steven Austin
Affiliation:
Medical Research Council, Dunn Nutritional Laboratory, Downhams Lane, Milton Road, Cambridge CB4 lXJ
John K. Beresford
Affiliation:
University Department of Paediatrics, The Stephenson Unit, Sheffield Children's Hospital, Western Bank, Sheffield S1O 2TH
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Abstract

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The effect of riboflavin deficiency on gastrointestinal Fe distribution and loss was studied in weanling rats. Riboflavin deficiency was associated with a significant increase in crypt depth in the upper and mid small intestine and a twofold increase in the rate of crypt cell production compared with weight-matched and ad lih.-fed control rats. The rate of loss of endogenous Fe, measured as faecal 59Fe after intraperitoneally administered 59Fe, was twice that from riboflavin-deficient rats compared with weightmatched controls. We suggest that while there may be a contribution from turnover of enterocytes with an enhanced Fe content, enhanced Fe loss associated with riboflavin deficiency is due predominantly to an accelerated rate of small-intestinal epithelial turnover.

Keywords

Riboflavin deficiencyIronRatCell turnoverSmall intestine
Type
Interactions Between Riboflavin Status and Iron
Information
British Journal of Nutrition , Volume 69 , Issue 2 , March 1993 , pp. 553 - 561
Copyright
Copyright © The Nutrition Society 1993

References

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