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Rebalancing essential amino acids intake by self-selection in the rat

Published online by Cambridge University Press:  09 March 2007

Gilles Fromentin  and
Stylianos Nicolaidis
Gilles Fromentin
Affiliation:
1Laboratoire de Neurobiologie des Régulations, CNRS URA 1860, Collège de France, 11 Place Marcellin Berthelot, F75231 Paris Cedex 05, France
Stylianos Nicolaidis
Affiliation:
1Laboratoire de Neurobiologie des Régulations, CNRS URA 1860, Collège de France, 11 Place Marcellin Berthelot, F75231 Paris Cedex 05, France
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Abstract

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The purpose of the present study was to assess whether rats are capable of selecting the right proportions of two diets that are individually inappropriate in terms of essential amino acid composition to satisfy their amino acid requirements. Rats were offered a choice of one protein-free regimen and another devoid of only one essential amino acid (either threonine or isoleucine) set up in such a way as to provide amino acid balance if they were consumed in 1/3 and 2/3 proportions respectively. Preliminary experiments had established that all our diets were aversive by themselves except for the 60 g casein/kg diet. Rats did reach almost the necessary proportion with, according to published standards (National Research Council, 1978), some excess in isoleucine intake. In addition, given access to two aversive diets that were each nutritionally inadequate, rats showed no aversion and gained body weight when they had the opportunity to consume both of them. Beyond the capacity that rats have of rebalancing their micronutrient intake, the present experiment brings out the idea that the imbalance-induced aversion: preference ratio may be completely upset when this omnivore has access to more than one feed.

Keywords

Dietary choicePreferenceConditioned taste aversion
Type
Essential amino acid selection by the rat
Information
British Journal of Nutrition , Volume 75 , Issue 5 , May 1996 , pp. 669 - 682
Copyright
Copyright © The Nutrition Society 1996

References

Gietzen, D. W. (1993). Neural mechanisms in the responses to amino acid deficiency. Journal of Nutrition 123, 610–625.CrossRefGoogle ScholarPubMed
Gietzen, D. W., McArthur, L. H., Thiesen, J. C. & Rogers, Q. R. (1992). Learned preference for the limiting amino acid in rats fed a threonine deficient diet. Physiology and Behavior 51, 909–914.CrossRefGoogle ScholarPubMed
Halstead, W. C. & Gallagher, B. (1962). Autoregulation of amino acids in the albino rat. Journal of Comparative and Physiological Psychology 55, 107–111.CrossRefGoogle ScholarPubMed
Harper, A. E. (1959). Sequence in which the amino-acids of casein become limiting for the growth of the rat. Journal of Nutrition 67, 109–122.CrossRefGoogle ScholarPubMed
Harper, A. E., Benevenga, N. J. & Wohlhueter, R. M. (1970). Effects of ingestion of disproportionate amounts of amino acids. Physiological Reviews 80, 428–458.CrossRefGoogle Scholar
Harris, L. J., Hargreaves, F. & Ward, A. (1933). Appetite and choice of diet. The ability of the vitamin B deficient rat to discriminate between diets containing and lacking the vitamin. Proceedings of the Royal Society, Series B 113, 161–190.Google Scholar
Leung, P. M. B. & Rogers, Q. R. (1985). Effect of amino imbalance and deficiency on dietary choice patterns of rats. Physiology and Behavior 37, 747–758.CrossRefGoogle Scholar
Leung, P. M. B., Rogers, Q. R. & Harper, A. E. (1968). Effect of amino acid imbalance on dietary choice. Journal of Nutrition 95, 483–492.CrossRefGoogle ScholarPubMed
Naito-Hoopes, M., Gietzen, D. W., McArthur, L. H. & Rogers, Q. R. (1993). Learned preference and aversion for complete and isoleucine-devoid diet. Physiology and Behavior 53, 485–494.CrossRefGoogle Scholar
National Research Council (1978). Nutrient requirements of the laboratory rat. In Nutrient Requirements of Laboratory Animals. Washington, DC: National Academy of Sciences.Google Scholar
Potier de Courcy, G., Durand, G., Abraham, J. & Gueguen, L. (1989). Recommendations of the feeding conditions of the laboratory animals (rats and mice). CNERNA (Centre National d'Etudes et de Recommandations sur la Nutrition et l'Alimentation). Science des Aliments 209–217.Google Scholar
Richter, C. P. (1956). Salt appetite in mammals: its dependence on instinct and metabolism. In l'lnstinct dans le Comportement des Animaux et de l'Homme, pp. 577–629 [Autuori, M., editor]. Paris; Masson et Cie.Google Scholar
Rodgers, W. (1967). Specificity of specific hungers. Journal of Comparative and Physiological Psychology 64, 49–58.CrossRefGoogle ScholarPubMed
Rogers, Q. R. & Harper, A. E. (1970). Selection of a solution containing histidine by rats feeding on an histidine imbalanced diet. Journal of Comparative and Physiological Psychology 72.CrossRefGoogle Scholar
Rogers, Q. R. & Leung, P. M. B. (1977). The control of food intake: when and how are amino acids involved? In Chemical Senses and Nutrition, pp. 213–249, [Kare, M. R., editor]. New York: Academic Press.CrossRefGoogle Scholar
Schiffman, S. S. & Engelhard, H. H. (1976). Taste of dipeptides. Physiology and Behavior 7, 523–535.CrossRefGoogle Scholar
Scott, E. M. & Quint, E. (1946). Self selection of diet: appetites for B vitamins. Journal of Nutrition 37, 285–291.CrossRefGoogle Scholar
Sidransky, H. & Rechcigl, J. R. Miloslav (1962). Chemical pathology of acute amino acid deficiencies: comparison of morphologic and biochemical changes in young rats fed protein-free or threonine diets. Journal of Nutrition 78, 269–277.CrossRefGoogle ScholarPubMed
Yamamoto, Y., Suzuki, M. & Murumatsu, K. (1985). Self selection of dietary threonine in the rat and the effect of taste stimuli on its selection. Agricultural and Biological Chemistry 49, 2849–2859.CrossRefGoogle Scholar