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The Blood-Brain Barrier in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Harry V. Vinters  and
William M. Pardridge
Harry V. Vinters*
Affiliation:
Department of Pathology, University of California, Los Angeles Brain Research Institute, University of California, Los Angeles
William M. Pardridge
Affiliation:
Department of Medicine (Endocrinology), University of California, Los Angeles Brain Research Institute, University of California, Los Angeles
*
Dept. of Pathology (Neuropathology), UCLA Medical Center, CHS 18-170, Los Angeles, CA USA 90024
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Abstract:

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The current evidence for and against abnormalities of the blood-brain barrier in “normal” aging and Alzheimer's disease is reviewed. Recent studies of cerebral amyloid angiopathy, a microangiopathy commonly observed in Alzheimer's disease and one suggested to result from blood-brain barrier derangement, are discussed with particular attention to the biochemical nature of the vascular amyloid material, and features it shares with the amyloid found in senile plaque cores and with neurofibrillary tangles. Modern techniques that will probably clarify blood-brain barrier pathophysiology are reviewed.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 446 - 448
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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