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Chronic Aluminum-Induced Motor Neuron Degeneration: Clinical, Neuropathological and Molecular Biological Aspects

Published online by Cambridge University Press:  18 September 2015

Michael J. Strong  and
Ralph M. Garruto
Michael J. Strong*
Affiliation:
Department of Clinical Neurological Sciences, The University of Western Ontario, London
Ralph M. Garruto
Affiliation:
Laboratory of Central Nervous System Studies, National Institutes of Health, Bethesda
*
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada N6A 5A5
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Abstract:

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The monthly intracisternal inoculation of young adult New Zealand white rabbits with low-dose (100 Μg) aluminum chloride induces aggregates of phosphorylated neurofilament that mimics the intraneuronal inclusions of amyotrophic lateral sclerosis. The chronic progressive myelopathy and topographically-specific motor neuron degeneration that occurs in the absence of suppressions of neurofilament messenger RNA levels in this model contrasts with the acute fulminant encephalomyelopathy and nonspecific gene suppressions that occur subsequent to high-dose (1000 Μg) aluminum chloride inoculations. Further analysis of this unique model of chronic motor system degeneration can be expected to provide additional insights into the pathogenesis of amyotrophic lateral sclerosis.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 428 - 431
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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