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HLA and Complement Typing in Olivo-ponto-cerebellar Atrophy

Published online by Cambridge University Press:  18 September 2015

J. P. Wastiaux ,
G. Lamoureux ,
J. P. Bouchard ,
A. Durivage ,
C. Barbeau  and
A. Barbeau
J. P. Wastiaux
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
G. Lamoureux
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
J. P. Bouchard
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
A. Durivage
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
C. Barbeau
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Section on Clinical Immunology, Centre de Recherches en Immunologie, Institut Armand Frappier, Laval; l'Hôpital de l'Enfant-Jésus, Québec; and the Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Summary:

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HLA antigen typing was carried out in a family with an autosomal dominant form of spinocerebellar degeneration [possibly olivoponto cerebellar atrophy (O.P.C.A.) — Type 1] . Eleven ataxic patients, three possibly ataxic subjects, two unrelated spouses and 13 clinically normal at risk siblings were typed for ABO and Rh blood groups, HLA-A and HLA-B antigens, C4 component of the complement and a number of other serum proteins (Clq, (β -1A, (β-1C, C5, (β -lipoproteins). No solid evidence for linkage between the ataxia gene and the HLA or C4 loci could be demonstrated in this family. Certain serum proteins, and particularly β -lipoproteins were found to be significantly reduced in some sub-groups of subjects.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 75 - 81
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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