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Parkinson's Disease and Exposure to Rural Environmental Factors: A Population Based Case-Control Study

Published online by Cambridge University Press:  18 September 2015

Karen M. Semchuk ,
Edgar J. Love  and
Robert G. Lee
Karen M. Semchuk*
Affiliation:
Departments of Community Health Sciences, Faculty of Medicine, The University of Calgary, Calgary
Edgar J. Love
Affiliation:
Departments of Community Health Sciences, Faculty of Medicine, The University of Calgary, Calgary
Robert G. Lee
Affiliation:
Departments of Clinical Neurosciences, Faculty of Medicine, The University of Calgary, Calgary
*
Centre for Agricultural Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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To determine whether a history of exposure to rural environmental factors leads to an increased likelihood of developing idiopathic Parkinson's disease, we conducted a case-control study of 130 cases and 260 randomly selected community controls (matched with the cases by sex and age ± 2.5 years at a ratio of 2 controls: 1 case) in the city of Calgary. The data were collected by personal interviews and were analyzed using conditional logistic regression for matched sets. The ages of the cases ranged from 36.5 to 90.7 years (mean = 68.5 ± 11.3 years). The mean age at diagnosis was 61.1 ± 12.4 years. The mean duration of disease was 7.8 ± 0.6 years. Eleven (9.1%) cases were diagnosed before age 40. In this sample from the Province of Alberta, Canada, no significant increase in risk for Parkinson's disease was associated with a history of rural living, farm living, or well water drinking in early childhood or at any time during the first 45 years of life.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 3 , August 1991 , pp. 279 - 286
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Kessler, II. Parkinson’s disease in epidemiologic perspective. Adv Neurol 1978; 19: 355–384.Google ScholarPubMed
2.Kurtzke, JF. Neuroepidemiology. Ann Neurol 1984; 16: 265–277.CrossRefGoogle ScholarPubMed
3.Mjones, H. Paralysis agitans. A clinical genetic study. Acta Psychiat Neurol Scan 1949; 25 (Suppl): 1–195.Google Scholar
4.Duvoisin, RC, Gearing, FR, Schweitzer, M, et al. A family study of parkinsonism. In: Barbeau, A, Brunette, JR, eds. Progress in Neurogenetics. Amsterdam: Excerpta Medica, 1969: 494–496.Google Scholar
5.Martin, WE, Young, WI, Anderson, VE. Parkinson’s disease: a genetic study. Brain 1973; 96: 496–506.CrossRefGoogle ScholarPubMed
6.Marttila, RJ, Rinne, UK. Arteriosclerosis, heredity, and some previous infections in the etiology of Parkinson’s disease. A case-control study. Clin Neurol Neurosurg 1976; 76: 46–56.CrossRefGoogle Scholar
7.Marttila, RJ, Rinne, UK. Epidemiology of Parkinson’s disease in Finland. Acta Neurol Scand 1976; 53: 81–102.Google ScholarPubMed
8.Heston, LLDementia associated with Parkinson’s disease. J Neurol Neurosurg Psychiatry 1980; 43: 846–848.CrossRefGoogle ScholarPubMed
9.Roy, M, Boyer, L, Barbeau, A. A prospective study of 50 cases of familial Parkinson’s disease. Can J Neurol Sci 1983; 10: 37–42.CrossRefGoogle ScholarPubMed
10.Ward, CD, Duvoisin, RC, Ince, SE, et al. Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology 1983; 33: 815–824.CrossRefGoogle Scholar
11.Ward, CD, Duvoisin, RC, Ince, SE, et al. Parkinson’s disease in twins. Adv Neurol 1984; 40: 341–344.Google ScholarPubMed
12.Bharucha, NE, Stokes, L, Schoenberg, BS, et al. A case control study of twin pairs discordant for Parkinson’s disease: a search for environmental risk factors. Neurology 1986; 36: 284–288.CrossRefGoogle ScholarPubMed
13.Duvoisin, RC. Genetics of Parkinson’s disease. Adv Neurol 1986; 45: 307–311.Google Scholar
14.Jankovic, J, Reches, A. Parkinson’s disease in monozygotic twins. Ann Neurol 1986; 19: 405–408.CrossRefGoogle ScholarPubMed
15.Quinn, NP, Critchley, P, Marsden, CD. Young onset parkinsonism. Neurology 1986; 36 (Suppl 1): 215.Google Scholar
16.Poskanzer, DC, Schwab, RS. Cohort analysis of Parkinson’s syndrome: evidence for a single etiology related to sub clinical infection about 1920. J Chronic Dis 1963; 16: 961–973.CrossRefGoogle Scholar
17.Gibbs, CJ, Jr Gajdusek, DC. Amyotrophic lateral sclerosis, Parkinsonx’s disease and the amyotrophic lateral sclerosis parkinson- dementia complex of Guam: a review summary of attempts to demonstrate infection as the etiology. J Clin Pathol 1972; 25 (Suppl 6): 132–140.CrossRefGoogle Scholar
18.Marttila, RJ, Rinne, UK, Tiilikainen, A. Virus antibodies in Parkinson’s disease. J Neurol Sci 1982; 54: 227–238.CrossRefGoogle ScholarPubMed
19.Elizan, TS, Casals, J. The viral hypothesis in parkinsonism. J Neural Transm 1983; (Suppl 19): 75–88.Google ScholarPubMed
20.Ragozzino, MW, Rajput, LT, Tiilikainen, AH. Investigation of the asso-ciation between herpes zoster Parkinson’s disease. Neuroepidemiology 1983; 2: 89–92.CrossRefGoogle Scholar
21.Rajput, AH, Orford, KP, Beard, CM, et al. Epidemiology of parkinsonism: incidence classification mortality. Ann Neurol 1984; 16: 278–282.CrossRefGoogle ScholarPubMed
22.Kondo, L. Epidemiological evaluations of risk factors in Parkinson’s disease. Adv Neurol 1986; 45: 289–293.Google Scholar
23.Kessler, II. Epidemiologic studies of Parkinson’s disease II. a hospital- based survey. Am J Epidemiol 1972; 95: 308–318.CrossRefGoogle Scholar
24.Kessler, II. Epidemiologic studies of Parkinson’s disease III. a community- based survey. Am J Epidemiol 1972; 96: 242–254.CrossRefGoogle Scholar
25.Kondo, K. Epidemiological clues for the etiology of Parkinson’s disease. Adv Neurol 1984; 40: 345–351.Google ScholarPubMed
26.Lang, AE, Blair, RD. Parkinson’s disease in 1984: an update. Can Med Assoc J 1984; 131: 1031–1037.Google ScholarPubMed
27.Lombard, A, Gelfand, M. Parkinson’s disease in the African. Cent AfrJ Med 1978; 28: 5–8.Google Scholar
28.Rajput, AH. Epidemiology of Parkinson’s disease. Can J Neurol Sci 1984; 11: 156–159.CrossRefGoogle ScholarPubMed
29.Marttila, RJ, Rinne, UK. Clues from epidemiology of Parkinson's disease. Adv Neurol 1986; 45: 285–288.Google Scholar
30.Goldman, JE, Yen, SH, Chiu,, FC, et al. Lewy bodies of Parkinson’s disease contain neurofilament antigens. Science 1983; 221: 1082–1084.CrossRefGoogle ScholarPubMed
31.Gajdusek, DC. Hypothesis: interference with axonal transport of neurofilament as a common pathogenic mechanism in certain diseases of the central nervous system. N Engl J Med 1985; 312: 714–718.CrossRefGoogle Scholar
32.Kahn, J, Anderton, BJ, Gibb, WR, et al. Neuronal filaments in Alzheimer’s Pick’s Parkinson's disease. N Engl J Med 1985; 313: 520.Google Scholar
33.Rasool, CA, Selkoe, DJ. Sharing of specific antigens by generating neurons in Pick’s disease Alzheimer’s disease. N Engl J Med 1985; 312: 700–705.CrossRefGoogle Scholar
34.Robins, JH, Otsuka, F, Tarone, RE,et al. Parkinson’s disease Alzheimer’s disease: hypersensitivity to x-rays in cultured cell lines. J Neurol Neurosurg Psychiatry 1985; 48: 916–923.CrossRefGoogle Scholar
35.Ogawa, H, Tominaga, S, Kubo, N,et al. Shinshin-lgaku (Psychosom Med). 1984; 24: 467–477.Google Scholar
36.Golbe, LI, Duvoisin, RC. Smoking and Parkinson’s disease. Neurology 1985; 35 (Suppl 1): 275.Google Scholar
37.Snyder, SH, D’Amato, RJ. Predicting Parkinson’s disease. Nature 1985; 317: 198–199.CrossRefGoogle ScholarPubMed
38.Barbeau, A, Roy, M. Familial subsets in idiopathic Parkinson’s disease. Can J Neurol Sci 1984; 11: 144–150.CrossRefGoogle ScholarPubMed
39.Marttila, RJ, Rautakorpi, I, Rinne, UK. The relation of essential tremor to Parkinson’s disease. J Neurol Neurosurg Psychiatry 1984; 47: 734–735.CrossRefGoogle ScholarPubMed
40.Findley, LJ, Cleeves, L. The relation of essential tremor to Parkinson’s disease. J Neurol Neurosurg Psychiatry 1985; 48: 192.CrossRefGoogle ScholarPubMed
41.Geraghty, JJ, Jankovic, J, Zetusky, WK. Association between essential tremor and Parkinson’s disease. Ann Neurol 1985; 17: 329–333.CrossRefGoogle ScholarPubMed
42.Lang, AE, Kierans, C, Blair, RD. Family history of tremor in Parkinson’s disease compared with those of controls patients with idiopathic dystonia. Adv Neurol 1986; 45: 313–316.Google Scholar
43.Ohlson, CG, Hagstedt, C. Parkinson’s disease and occupational exposure to organic solvents agricultural chemicals mercury: a case-referent study. Scand J Work Environ Health 1981; 7: 252–256.CrossRefGoogle ScholarPubMed
44.Calne, DB, Langston, JW. Aetiology of ParkinsonParkinson's disease. Lancet 1983; 2: 1457–1459.CrossRefGoogle ScholarPubMed
45.Langston, JW, Ballard, PA. Parkinson’s disease in a chemist working with MPTP. N Engl J Med 1983; 309: 310.Google Scholar
46.Langston, JW, Ballard, PA, Tetrud, JW, et al. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979–980.CrossRefGoogle ScholarPubMed
47.Burns, RS, Chiueh, CC, Markey, SP, et al. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4 phenyl- 1236-tetrahydropyridine. Proc Natl Acad Sci USA 1983; 80: 4546–4550.CrossRefGoogle Scholar
48.Langston, JW, Fomo, LS, Rebert, CS, et al. Selective nigral toxicity after systemic administration of l-methyl-4 phenyl-1236- tetrahydropyridine MPTP) in the squirrel monkey. Brain Res 1983; 292: 390–394.Google Scholar
49.Barbeau, A. Etiology of Parkinson’s disease: A research strategy. Can J Neurol Sci 1984; 11: 24–28.CrossRefGoogle ScholarPubMed
50.Rajput, AH, Stern, W, Christ, A, Laverty, W. Etiology of Parkinson’s disease: environmental factor(s). Neurology 1984; 34(Suppl 1.1): 207.Google Scholar
51.Barbeau, A, Roy, M, Langston, W. Neurological consequence of industrial exposure to l-methyl-4-phenyl 1236 tetrahydropyridine (Letter). Lancet 1985; 1: 747.CrossRefGoogle Scholar
52.Barbeau, A, Roy, M, Paris, S, et al. Ecognetics of Parkinson’s disease: 4-hydroxylation of desbrisoquine. Lancet 1985; 2: 1213–1216.CrossRefGoogle Scholar
53.Barbeau, A, Roy, M, Cloutier, T, et al. Environmental genetic factors in the etiology of Parkinson’s disease. Adv Neurol 1986; 45: 299–306.Google Scholar
54.Duvoisin, RC. Etiology of Parkinson’s disease: current concepts. Clin Neuropharmacol 1986; 9(Suppl 1): S3-S11.CrossRefGoogle ScholarPubMed
55.Fruncillo, RJ. Toxin-induced parkinsonism: recent developments. Am Fam Physician 1986; 33: 251–254.Google ScholarPubMed
56.Tetrud, JW, Langston, JW. Early parkinsonism in humans due to MPTP exposure). Neurology 1986; 36(Suppl 1): 308.Google Scholar
57.Tetrud, JW, Langston, JW, Redmond, DE, et al. MPTP-induced tremor in human non-human primates. Neurology 1986; 36(Suppl 1): 308.Google Scholar
58.Snyder, SH, D’Amato, RJ. MPTP: A neurotoxin relevant to the pathophysiology of Parkinson’s disease. The 1985 George C. Cotzias lecture. Neurology 1986; 36: 250–258.CrossRefGoogle Scholar
59.Tanner, CM. Influence of environmental factors on the onset of Parkinsonߣs disease. Neurology 1986; 36(Suppl 1): 215.Google Scholar
60.Rajput, AH, Uitti, RJ, Stern, W, et al. Geography, drinking water chemistry, pesticides, herbicides and the etiology of Parkinson’s disease. Can J Neurol Sci 1987; 14: 414–418.CrossRefGoogle ScholarPubMed
61.Tanner, CM, Chen, B, Wang, WZ, et al. Environmental factors in the etiology of Parkinson’s disease. Can J Neurol Sci 1987; 14: 419–423.CrossRefGoogle ScholarPubMed
62.Li, SC, Schoenberg, BS, Wang, C, et al. A prevalence survey of Parkinson’s disease other movement disorders in the People’s Republic of China. Arch Neurol 1985; 42: 655–657.CrossRefGoogle ScholarPubMed
63.Schoenberg, BS. Descriptive epidemiology of Parkinson’s disease: disease distribution and hypothesis formulation. Adv Neurol 1986; 45: 277–283.Google Scholar
64.Calne, DB. Is “Parkinson’s disease” one disease?. J Neurol Neurosurg Psychiatry 1989; June (Suppl 4): 18–21.CrossRefGoogle ScholarPubMed
65.Rajput, AH, Uitti, RJ, Stern, W, et al. Early onset Parkinson’s disease in Saskatchewan - environmental considerations for etiology. Can J Neurol Sci 1986; 13: 312–316.CrossRefGoogle ScholarPubMed
66.Rodgers-Johnson, P, Garruto, RM, Yanagihara, R, et al. Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam: a 30 year evaluation of clinical neuropathologic trends. Neurology 1986; 36: 7–13.CrossRefGoogle ScholarPubMed
67.Tanner, CM, Chen, B, Wang, W, et al. Environmental factors and Parkinson’s disease: a case-control study in China. Neurology 1989; 39: 660–664.CrossRefGoogle ScholarPubMed
68.Ho, SC, Woo, J, Lee, CM. Epidemiologic study of Parkinson’s disease in Hong Kong. Neurology 1989; 39: 1314–1318.CrossRefGoogle ScholarPubMed
69.Koller, W, Veterre-Overfield, B, Gray, C, et al. Environmental risk factors in Parkinson’s disease. Neurology 1990; 40: 1218–1221.CrossRefGoogle ScholarPubMed
70.Hertzman, C, Wiens, M, Bowering, D, et al. Parkinson’s disease: a case-control study of occupational environmental risk factors. Am J Ind Med 1990; 17: 349–355.CrossRefGoogle ScholarPubMed
71.Zayed, J, Ducic, S, Campanella, G, et al. Facteurs environnementaux dans L’etiologie de la maladie de Parkinson. Can J Neurol Sci 1990; 17: 286–291.CrossRefGoogle Scholar
72.Thiessen, B, Rajput, AH, Laverty, W, et al. Age, environments and the number of substantia nigra neurons. Adv Neurol 1990; 53: 201–206.Google ScholarPubMed
73.Tuchfarber, AJ, Klecka, WR. Random digit dialing: lowering the cost of victimization surveys. University of Cincinnati: Police Foundation, 1976.Google Scholar
74.Waksberg, J. Sampling methods for random digit dialing. Journal of the J Am Stat Assoc 1978; 73: 40–46.CrossRefGoogle Scholar
75.Groves, RM, Kahn, RL. Surveys by telephone: a national comparison with personal interviews. Toronto: academic Press, 1979.Google Scholar
76.Hoover, RN, Hartge Strasser, P. Artificial sweeteners and human bladder cancer: Preliminary Results. Lancet 1980; 1: 837–840.CrossRefGoogle ScholarPubMed
77.Ryan, BF, Joiner, BL, Ryan, TA. Minitab handbook. 2nd ed. Boston: Duxbury Press, 1985.Google Scholar
78.SPSS Inc. SPSS data entry II for the IBM PC/XT/AT (Computer Program). Chicago: SPSS Inc, 1987.Google Scholar
79.SPSS Inc. SPSSx (Computer Program). Chicago: SPSS Inc, 1987.Google Scholar
80.Breslow, NE, Day, NE. Statistical methods in cancer research: I. the analysis of case-control studies. Lyon: International Agency for Research on Cancer 1980, 1989: 161–190.Google Scholar
82.Statistics Epidemiology Research Corporation. EGRET (Computer Program). Seattle: SERC Software Division, 1990.Google Scholar
82.Walter, SD. Matched case-control studies with a variable number of controls per case. Appl Statist 1980; 29: 172–179.CrossRefGoogle Scholar
83.Schlesselman, JJ. Case-control studies: design conduct analysis. New York: Oxford University Press, 1982:213–226.Google Scholar