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Regional Cerebral Blood Flow Statistical Patterns and Psychological Performance in Multi-Infarct Dementia and Alzheimer’s Disease

Published online by Cambridge University Press:  03 July 2018

Francisco I. Perez ,
Ninan T. Mathew ,
David A. Stump  and
John S. Mfyer
Francisco I. Perez*
Affiliation:
Departments of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas
Ninan T. Mathew
Affiliation:
Departments of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas
David A. Stump
Affiliation:
Departments of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas
John S. Mfyer
Affiliation:
Departments of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas
*
Department of Neurology, Baylor College of Medicine, 1200 Moursund Avenue, Houston, Texas 77030 U.S.A.
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Summary

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Multivariate data analysis statistical procedures were applied to identify regional cerebral blood flow (rCBF) patterns in patients with multi-infarct dementia (M.I.D.) and Alzheimer’s disease (A.D.) when compared to a control group (C). A fronto-temporal-parietal pattern was identified for the A.D. group. The M.I.D. group demonstrated a predominant temporal-parietal pattern. A discriminant function analysis classified 96% of the A.D. and C. patients correctly. One hundred percent hit rate was obtained in discriminating between M.I.D. and C. Discrimination of A.D. and M.I.D. obtained 82% diagnostic accuracy. When the three groups were compared the hit rate was 93%. Mean rCBF and mean relative weight of the gray matter (Wg) differences were found when each dementia group was compared with C.M.I.D. and A.D. did not differ in mean rCBF but significant differences were found for Wg, with M.I.D. having greater reduction. The performance on standardized psychological tests of two independent samples of A.D. and M.I.D. were compared. The Memory Quotient from the Wechsler Memory Scale was consistently more impaired for the A.D. group. No correlation between degree of psychological impairment and rCBF or W g reduction was found.

Résumé

Résumé

Des procédures statistiques d’analyse de données par variances multiples furent appliquées pour identifier les types de rCBF chez les patients atteints de démences secondaires à de multiples infarcissements (M.I.D.) et dans la maladie d’Alzheimer (A.D.), comparés à un groupe contrôle (C). Un pattern fronto-temporo-pariétal fut identifié pour le groupe A.D. Le groupe M.I.D. démontrait un type temporo-pariétal prédominant. Une analyse de fonctions discriminantes classifiait correctement 96% des patients A.D. et C Cent pour cent de réussite fut obtenu en discriminant les groupes M.I.D. et C La discrimination des groupes A.D. et M.I.D. donnait 82% d’exactitude de diagnostic. Quand les trois groupes étaient comparés, le taux de succès était de 83%. Des différences furent obtenues quant au rCBF moyen et quant au poids moyen relatif de la substance grise (Wg) quand chaque groupe de démence fut comparé au groupe contrôle. Les groupes M.I.D. et A.D. ne différaient pas en ce qui concerne le rCBF moyen mais des différences significatives furent trouvées pour le Wg, le groupe M.I.D. ayant la plus grande réduction. La performance aux tests psychologiques standardisés de deux groupes A.D. et M.I.D. indépendants fut comparée. Le quotient de mémoire mesuré par l’échelle de mémoire de Wechster fut constamment plus bas dans le groupe A.D. Nous n’avons trouvé aucune corrélation entre le degré d’ altération psychologique et la réduction de rCBF ou de Wg

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 1 , February 1977 , pp. 53 - 62
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

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