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Relationships Between Interictal Spiking and Seizures: Human and Experimental Evidence

Published online by Cambridge University Press:  18 September 2015

Jean Gotman
Jean Gotman*
Affiliation:
Montreal Neurological Institute, and Department of Neurology and Neurosurgery, McGill University, Montréal
*
Montreal Neurological Institute, Neurophysiology Department, 3801 University Street, Montreal, Québec, Canada H3A 2B4
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Abstract:

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Epileptic seizures of focal origin often occur unpredictably as do interictal spikes. It is often assumed that spikes increase prior to seizures of focal origin and that antiepileptic medication affects spikes and seizures in a parallel fashion. We review evidence that this assumption is invalid and that there is a clear dissociation between spikes and seizures: increases in spiking before seizures have not been clearly documented; decreases in antiepileptic medication do not result directly in increased spiking; seizures are often followed by long-lasting increases in spiking; finally, seizures are no more likely when spikes are frequent than when spikes are rare. It therefore appears that spikes and seizures are two quite distinct phenomena, both originating in the epileptic focus but varying over time differently from what is most often believed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S4 , November 1991 , pp. 573 - 576
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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