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Association between left ventricular ejection fraction and Kawasaki disease shock syndrome

Published online by Cambridge University Press:  20 February 2019

Huixian Qiu ,
Chen Li ,
Yuee He ,
Fengfeng Weng ,
Hongying Shi ,
Lulu Pan ,
Yuping Guo ,
Yuanhai Zhang ,
Rongzhou Wu  and
Maoping Chu
Huixian Qiu
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Chen Li
Affiliation:
Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yuee He
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Fengfeng Weng
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Hongying Shi
Affiliation:
Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China
Lulu Pan
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Yuping Guo
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Yuanhai Zhang
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Rongzhou Wu
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
Maoping Chu*
Affiliation:
Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China
*
Author for correspondence: M. Chu, Department of Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou 325000, China. Tel: +86-13857796736; Fax: +86-057788832693; E-mail: chmping@hotmail.com
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Abstract

Objective

This study was performed to explore the clinical features of Kawasaki disease shock syndrome and analyse the association between the left ventricular ejection fraction and Kawasaki disease shock syndrome.

Methods

We retrospectively reviewed the medical records of all consecutive inpatients with Kawasaki disease at Wenzhou Medical University Second Affiliated Hospital and Yuying Children’s Hospital in Wenzhou, China from January 2009 to December 2016. We compared the clinical characteristics, laboratory data, and left ventricular ejection fraction between patients with and without Kawasaki disease shock syndrome and analysed the effect of the left ventricular ejection fraction on Kawasaki disease shock syndrome under different clinical conditions of Kawasaki disease.

Results

In total, 1147 patients were diagnosed with Kawasaki disease. Of these 1147 patients, 17 were diagnosed with Kawasaki disease shock syndrome; 68 patients admitted to the hospital at the same time, ±2 weeks, with Kawasaki disease but without Kawasaki disease shock syndrome served as the control group. Compared with the control group, the Kawasaki disease shock syndrome group had a significantly higher incidence of coronary artery lesions, cardiac troponin I concentration, N-terminal prohormone of brain natriuretic peptide concentration, neutrophil count and ratio, alanine aminotransferase concentration, aspartate aminotransferase concentration, and C-reactive protein concentration and a significantly lower platelet count, serum albumin concentration, and left ventricular ejection fraction. A low left ventricular ejection fraction was associated with Kawasaki disease shock syndrome under different conditions of Kawasaki disease.

Conclusion

Among patients with Kawasaki disease, cardiac injury is more likely in those with Kawasaki disease shock syndrome than without, and a low left ventricular ejection fraction may be associated with the development of Kawasaki disease shock syndrome.

Keywords

Kawasaki diseaseshockleft ventricular ejection fraction
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 2 , February 2019 , pp. 178 - 184
Copyright
© Cambridge University Press 2019 

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Footnotes

*

Huixian Qiu and Chen Li contributed equally to the writing of this article.

Cite this article: Qiu H, Li C, He Y, Weng F, Shi H, Pan L, Guo Y, Zhang Y, Wu R, Chu M. (2019) Association between left ventricular ejection fraction and Kawasaki disease shock syndrome. Cardiology in the Young29: 178–184. doi: 10.1017/S1047951118002056

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