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Attention-deficit/hyperactivity disorder symptoms in children with surgically corrected Ventricular Septal Defect, Transposition of the Great Arteries, and Tetralogy of Fallot

Published online by Cambridge University Press:  13 January 2020

Line M. Holst Open the ORCID record for Line M. Holst [Opens in a new window] ,
Jonas B. Kronborg ,
Jens R. M. Jepsen ,
Jette Ø. Christensen ,
Niels G. Vejlstrup ,
Klaus Juul ,
Jesper V. Bjerre ,
Niels Bilenberg  and
Hanne B. Ravn
Line M. Holst*
Affiliation:
Department of Cardiothoracic Anaesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Jonas B. Kronborg
Affiliation:
Department of Cardiothoracic Anaesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Jens R. M. Jepsen
Affiliation:
Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research and Center for Neuropsychiatric Schizophrenia Research, Mental Health Services, Capital Region of Denmark, University of Copenhagen, Copenhagen, Denmark Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region of Denmark, University of Copenhagen, Copenhagen, Denmark
Jette Ø. Christensen
Affiliation:
Department of Paediatrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Niels G. Vejlstrup
Affiliation:
Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Klaus Juul
Affiliation:
Department of Paediatric Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Jesper V. Bjerre
Affiliation:
Department of Paediatric Cardiology, University of Aarhus, Aarhus, Denmark
Niels Bilenberg
Affiliation:
Department of Child and Adolescent Psychiatry, Odense, Mental Health Services in Region of Southern Denmark, University of Southern Denmark, Odense, Denmark
Hanne B. Ravn
Affiliation:
Department of Cardiothoracic Anaesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
*
Author for correspondence: L. M. Holst, MD, Department of Cardiothoracic Anaesthesiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100Copenhagen, Denmark. Tel: +45 35454141; Fax: +45 35452785; E-mail: line.marie.broksoe.holst.01@regionh.dk
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Abstract

Background:

Children with complex CHD are at risk for psychopathology such as severe attention-deficit/hyperactivity disorder symptoms after congenital heart surgery.

Objective:

The aim of this study was to investigate if children with Ventricular Septal Defect, Transposition of Great Arteries, or Tetralogy of Fallot have an increased occurrence of attention-deficit/hyperactivity disorder symptoms compared with the background population and to investigate differences between the three CHDs in terms of occurrence and appearance of attention-deficit/hyperactivity disorder symptoms.

Method:

A national register-based survey was conducted, including children aged 10–16 years with surgically corrected CHDs without genetic abnormalities and syndromes. The Attention-Deficit/Hyperactivity Disorder-Rating Scale questionnaires were filled in by parents and school teachers.

Results:

In total, 159 out of 283 questionnaires were completed among children with CHDs and compared with age- and sex-matched controls. Children with CHDs had significantly increased inattention scores (p = 0.009) and total attention-deficit/hyperactivity disorder scores (p = 0.008) compared with controls. Post hoc analyses revealed that children with Tetralogy of Fallot had significantly higher inattention scores compared with children both with Ventricular Septal Defect (p = 0.043) and controls (p = 0.004).

Conclusion:

Attention-deficit/hyperactivity disorder symptoms and inattention symptoms were significantly more frequent among children aged 10–16 years with CHDs, in particular in children with corrected Tetralogy of Fallot.

Keywords

CHDsattention-deficit/hyperactivity disorderVentricular Septal DefectTransposition of the Greater ArteriesTetralogy of Fallot
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 2 , February 2020 , pp. 180 - 187
Copyright
© Cambridge University Press 2020

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