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Increased QT and P-wave dispersion during attack-free period in pediatric patients with migraine attacks

Published online by Cambridge University Press:  17 April 2019

Oyku Tosun Open the ORCID record for Oyku Tosun [Opens in a new window]  and
Elif Karatoprak
Oyku Tosun*
Affiliation:
Department of Pediatric Cardiology, Medeniyet University Faculty of Medicine, Istanbul, Turkey
Elif Karatoprak
Affiliation:
Department of Pediatric Neurology, Medeniyet University Faculty of Medicine, Istanbul, Turkey
*
Author for correspondence: Oyku Tosun, Department of Pediatric Cardiology, Medeniyet University Faculty of Medicine, Istanbul, Turkey. Tel: +905053901685; Fax: +902165666614; E-mail: isaltosun@hotmail.com
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Abstract

Introduction:

Migraine is a common neurovascular disease characterised with recurrent attacks by pain-free periods. It has been suggested that both sympathetic and parasympathetic dysfunctions play a role in its pathophysiology.

Aim:

The aim of our study was to investigate the ECG changes during attack-free period in children with migraine, in terms of QTc interval, QTc, and P-wave dispersion to evaluate the autonomic nervous system disturbance.

Methods:

Sixty children who were diagnosed with migraine were included as patient group and 50 healthy, age- and body mass index-matched children who were examined for innocent murmur were included as control group. The patients’ routine ECG records were screened from the outpatient clinic files. The durations of P-wave, QT, and QTc intervals and dispersion values and heart rates (beats/minute) were compared between the patient and control groups.

Results:

P maximum and P dispersion were significantly higher, and P minimum was significantly lower in the migraine group compared with the control group. QT–QTc maximum and QT–QTc dispersion were significantly higher and QT–QTc minimum was significantly lower in the migraine group compared with the control group.

Conclusion:

According to our findings, although migraine patients were asymptomatic and no arrhythmia was detected in the surface ECG, sympathovagal balance in the sympathetic system, which may be disrupted in favour of the sympathetic system, should continue even in the attack-free period, and we should be careful in terms of serious arrhythmias that may develop in these patients.

Keywords

Autonomic nervous systemelectrocardiographymigrainepediatrics
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 4 , April 2019 , pp. 488 - 491
Copyright
© Cambridge University Press 2019 

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Footnotes

*

The study is a single-centre original retrospective article.

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