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Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring

Published online by Cambridge University Press:  28 August 2020

Anda Zhao Open the ORCID record for Anda Zhao [Opens in a new window] ,
Kena Zhao ,
Yuanqing Xia ,
Yong Yin ,
Jianzhen Zhu ,
Haifa Hong  and
Shenghui Li
Anda Zhao
Affiliation:
Department of Maternal, Child and Adolescent Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Kena Zhao
Affiliation:
Department of Maternal, Child and Adolescent Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yuanqing Xia
Affiliation:
Department of Maternal, Child and Adolescent Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yong Yin
Affiliation:
Department of Respiratory Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Jianzhen Zhu
Affiliation:
China Hospital Development Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Haifa Hong
Affiliation:
Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shenghui Li*
Affiliation:
Department of Maternal, Child and Adolescent Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
*
Address for correspondence: Shenghui Li, MD, PhD, School of Public Health, Shanghai Jiao Tong University, 227 South Chongqing Road, Huangpu District, Shanghai200025, China. Tel: +86 21 63846590; Fax: +86 21 63846590. E-mail: lsh9907@163.com; submission9907@163.com
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Abstract

Objective:

To explore if there is association between vitamin D supplementation through cod liver oil ingestion around the periconceptional period and the risk of developing severe CHD in offspring. Furthermore, we would examine the interaction between vitamin D and folic acid supplementation in the association.

Methods:

A case–control study was conducted in Shanghai Children’s Medical Center, in which, a total of 262 severe CHD cases versus 262 controls were recruited through June 2016 to December 2017. All children were younger than 2 years. To reduce potential selection bias and to minimise confounding effects, propensity score matching was applied.

Results:

After propensity score matching, vitamin D supplementation seemed to be associated with decreased odds ratio of severe CHD (odds ratio = 0.666; 95% confidence intervals: 0.449–0.990) in the multivariable conditional logistic analysis. Furthermore, we found an additive interaction between vitamin D and folic acid supplementation (relative excess risk due to interaction = 0.810, 95% confidence intervals: 0.386–1.235) in the association.

Conclusion:

The results suggested that maternal vitamin D supplementation could decrease the risk of offspring severe CHD; moreover, it could strengthen the protective effect of folic acid. The significance of this study lies in providing epidemiological evidence that vitamin D supplementation around the periconceptional period could be a potential nutritional intervention strategy to meet the challenge of increasing CHD.

Keywords

Pregnancyvitamin Dcod liver oilfolic acidCHD
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 10 , October 2020 , pp. 1445 - 1451
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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Footnotes

*

Anda Zhao and Kena Zhao contributed equally to this work.

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