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Pubertal status of children with congenital heart disease

Published online by Cambridge University Press:  08 July 2021

Zahra Ghaemmaghami ,
Zahra Khajali ,
Mohammad Dalili Open the ORCID record for Mohammad Dalili [Opens in a new window] ,
Zahra Fotovati ,
Maryam Moradian  and
Mahmood Sheikhfathollahi
Zahra Ghaemmaghami
Affiliation:
Endocrinologist, Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Zahra Khajali
Affiliation:
Cardiologist, Department of Adult Cardiology, Fellow in Adult Congenital Heart Disease, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Mohammad Dalili*
Affiliation:
Pediatric Cardiologist, Department of Pediatric Cardiology, Interventional Electrophysiologist, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Zahra Fotovati
Affiliation:
Department of Pediatric Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Maryam Moradian
Affiliation:
Pediatric Cardiologist, Department of Pediatric Cardiology, Advanced Echocardiographist, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Mahmood Sheikhfathollahi
Affiliation:
Assistant Professor of Biostatistics, Department of Research, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
*
Author for correspodence: Mohammad Dalili, Department of Pediatric Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Ave, Niayesh Intersection, Tehran, PO Code: 1995614331, Iran. Tel: +98 (21) 23923860; Cell: +98 912 230 3960; Fax: +98 (21) 22663212. E-mail: drdalili@yahoo.com
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Abstract

Background:

CHD influences many aspects of life in affected individuals. Puberty, a major aspect of development, is a concern for patients and families.

Objectives:

We investigated pubertal status in children and adolescents with CHD.

Methods:

Patients with CHD aged 6–18 were enrolled. Cardiac diagnoses were confirmed using history, examination, and paraclinical tools including echocardiography. An endocrinologist determined pubertal stages, and the second Tanner stages for pubarche (P2), thelarche (B2), and gonadarche (G2) were considered as the pubertal onset. A study with a large sample size on pubertal onset in a normal population was used for comparison.

Results:

Totally, 451 patients (228 girls and 223 boys) at a median (10th–90th percentile) age of 10.79 (8.02–14.28) years for the girls and 10.72 (8.05–14.03) years for the boys were enrolled. The median (10th–90th percentile) ages at B2 and P2 in the girls with CHD were 10.77 (9.55–12.68) and 10.53 (9.39–12.28) years, respectively, which were higher than the median ages of 9.74 (8.23–11.94) and 10.49 (8.86–12.17) years in the normal girls.

The median (10th–90th percentile) ages at G2 and P2 in the boys with CHD were 11.04 (8.85–13.23) and 11.88 (9.78–13.46) years, correspondingly, which were higher than the median ages of 9.01 (6.00–11.84) and 10.34 (6.84–13.10) years in the normal boys.

Conclusions:

Pubertal onset could be delayed in children with CHD when compared with the normal population.

Keywords

Congenital heart diseasepuberty delayedpubertygrowth
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 4 , April 2022 , pp. 574 - 578
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Noori, NM, Nakhaey Moghaddam, M, Teimouri, A, Boryri, T, Hassanabady, S. Evaluation of growth status in children with congenital heart disease: a case- control study. Int J Pediatr 2017; 5: 6503–6514.Google Scholar
Dalili, M, Meraji, SM, Davari, P, et al. Growth status of Iranian children with hemodynamically important congenital heart disease. Acta Medica Iranica 2011; 49: 103–108.Google ScholarPubMed
Moradian, M, Pouraliakbar, H, Mahdavi, M, Ghadrdoost, B, Faritous, Z, Fard, MS. Failure to thrive and bone growth retardation in cyanotic and acyanotic congenital heart diseases with and without pulmonary hypertension. Iranian Heart J 2017; 18: 35–41.Google Scholar
Marino, BS, Lipkin, PH, Newburger, JW, et al. Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association. Circulation 2012; 126: 1143–1172.CrossRefGoogle ScholarPubMed
Razzaghi Azar, M, Moghimi, A, Sadigh, N, et al. Age at the onset of puberty and Menarche in Iranian girls and boys. RJMS 2006; 13: 71–82.Google Scholar
Baumgartner, H, De Backer, J, Babu-Narayan, SV, et al. 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J 2021; 42: 563–645.CrossRefGoogle ScholarPubMed
Marshall, WA, Tanner, JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291–303.CrossRefGoogle ScholarPubMed
Marshall, WA, Tanner, JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13–23.CrossRefGoogle ScholarPubMed
Garibaldi, LR, Chemaitilly, W. Disorders of pubertal development. In: Kliegman RM, ST Geme III JW, Blum NJ, et al (eds.) Nelson Textbook of Pediatrics, 21st edn, 2. Elsevier, , Canada, 2020: 2899–2912.Google Scholar
Pozo, J, Argente, J. Delayed puberty in chronic illness. Best Pract Res Clin Endocrinol Metab 2002; 16: 73–90.CrossRefGoogle ScholarPubMed
Currie, C. Development is not the same as ageing: the relevance of puberty to health of adolescents. Int J Public Health 2019; 64: 149–150.CrossRefGoogle Scholar
Patel, L. Growth and chronic disease. Annales Nestlé (English ed) 2007; 65: 129–136.CrossRefGoogle Scholar
Soliman, A, De Sanctis, V, Elalaily, R, Bedair, S. Advances in pubertal growth and factors influencing it: can we increase pubertal growth? Indian J Endocrinol Metab 2014; 18 (Suppl 1): S53–S62.CrossRefGoogle ScholarPubMed
Dündar, B, Akçoral, A, Saylam, G, et al. Chronic hypoxemia leads to reduced serum IGF-I levels in cyanotic congenital heart disease. J Pediatr Endocrinol Metab: JPEM. 2000; 13: 431–436.CrossRefGoogle ScholarPubMed
Ehlers, KH. Growth failure in association with congenital heart disease. Pediatr Ann 1978; 7: 750–759.Google ScholarPubMed
Cohen, MI, Bush, DM, Ferry, RJ Jr., et al. Somatic growth failure after the Fontan operation. Cardiol Young 2000; 10: 4474–4457.CrossRefGoogle ScholarPubMed
Mauras, N. Growth hormone and sex steroids. Interactions in puberty. Endocrinol Metab Clin North America 2001; 30: 529–544.CrossRefGoogle ScholarPubMed
Drenthen, W, Hoendermis, ES, Moons, P, et al. Menstrual cycle and its disorders in women with congenital heart disease. Congenit Heart Dis 2008; 3: 277–283.CrossRefGoogle ScholarPubMed
Khajali, Z, Ziaei, S, Maleki, M. Menstrual disturbances in women with congenital heart diseases. Res Cardiovasc Med [Internet] 2016; 5: e32512.CrossRefGoogle Scholar