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Pulmonary hypertension and mitral regurgitation in an infant with an anatomically normal mitral valve

Published online by Cambridge University Press:  04 December 2020

Ryan Hoang ,
William Cohen Open the ORCID record for William Cohen [Opens in a new window] ,
Shireen Mukadam ,
Pamela Combs ,
Tarek Husayni ,
Chawki El-Zein ,
Luca Vricella  and
Narutoshi Hibino
Ryan Hoang
Affiliation:
Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA
William Cohen
Affiliation:
Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA
Shireen Mukadam
Affiliation:
Advocate Children’s Heart Institute, Advocate Children’s Hospital, Oak Lawn, IL, USA
Pamela Combs
Affiliation:
Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA
Tarek Husayni
Affiliation:
Advocate Children’s Heart Institute, Advocate Children’s Hospital, Oak Lawn, IL, USA
Chawki El-Zein
Affiliation:
Advocate Children’s Heart Institute, Advocate Children’s Hospital, Oak Lawn, IL, USA
Luca Vricella
Affiliation:
Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA Advocate Children’s Heart Institute, Advocate Children’s Hospital, Oak Lawn, IL, USA
Narutoshi Hibino*
Affiliation:
Section of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA Advocate Children’s Heart Institute, Advocate Children’s Hospital, Oak Lawn, IL, USA
*
Author for correspondence: Narutoshi Hibino, MD/PhD, Section of Cardiac Surgery, Department of Surgery, The University of Chicago, 5841 S. Maryland, Rm E-500, MC5040, Chicago, IL60637, USA. Tel: 773–834–3707; Fax: 773–702–4187. E-mail: nhibino@surgery.bsd.uchicago.edu
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Abstract

A full-term, female presented on her date of birth with severe pulmonary hypertension (PH) and mitral regurgitation (MR), requiring veno-arterial extracorporeal membrane oxygenation. After the treatment, her PH and MR were resolved with no anatomic abnormality present. We propose a positive feedback loop of PH causing right ventricular dilation and interventricular septal shifts, worsening MR, and elevated left atrial, and potentially pulmonary, pressures.

Keywords

Mitral regurgitationpulmonary hypertensionPPHNseptal geometryfeedback loop
Type
Brief Report
Information
Cardiology in the Young , Volume 31 , Issue 3 , March 2021 , pp. 476 - 478
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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