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Cerebrospinal Fluid Oxytocin Levels in Trichotillomania

Published online by Cambridge University Press:  07 November 2014

C. Neill Epperson ,
Linda Carpenter ,
William G. North  and
Christopher J. McDougle
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Abstract

Several lines of evidence suggest that the neuropeptide oxytocin (OT) may be involved in the pathophysiology of obsessive-compulsive behavior in humans and repetitive grooming behavior in animals. Trichotillomania (TTM), which is characterized by chronic hair pulling, may be conceptualized as a disorder of pathologic grooming. To investigate the role of OT in TTM, the cerebrospinal fluid (CSF) levels of OT in nine women with TTM and nine healthy female controls were measured. Early findings from this ongoing study fail to demonstrate a significant difference in CSF OT levels between women with TTM and healthy female controls.

Type
Feature Article
Information
CNS Spectrums , Volume 3 , Issue 9: Trichotillomania: A New Understanding , October 1998 , pp. 52 - 55
Copyright
Copyright © Cambridge University Press 1998

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References

REFERENCES

1.Insel, TR. Oxytocin-a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Psychoneuroendocrinology. 1992;17:3–35.Google Scholar
2.Drago, FP, Pedersen, CA, Caldwell, JD, Prange, JE. Oxytocin potently enhances novelty-induced grooming behavior in the rat. Brain Res. 1986;368:287–295.Google Scholar
3.Pedersen, CA, Prange, AJ, Monroe, YZ, Prange, AJ. Oxytocin induces maternal behavior in virgin female rats. Science. 1982;216:648–649.CrossRefGoogle ScholarPubMed
4.Pedersen, CA, Caldwell, JD, Johnson, FR, Fort, SA, Prange, AJ. Oxytocin antiserum delays onset of ovarian steriod-induced maternal behavior. Neuropeptides. 1985;6:175–182.Google Scholar
5.Leckman, JF, Goodman, WK, North, WG, et al.The role of central oxytocin in obsessive-compulsive disorder and related behavior. Psychoneuroendocrinology. 1994;19:723–749.Google Scholar
6.Epperson, CN, McDougle, CJ, Price, LH. Intranasal oxytocin in trichotillomania. Biol Psychiatry. 1996;40:559–561.Google Scholar
7.Leekman, JF, North, W, Price, LH, et al.Elevated levels of CSF oxytocin in obsessive compulsive disorder patients without a personal or family history of tics. Arch Gen Psychiatry. 1994;51:782–792.Google Scholar
8.Epperson, CN, McDougle, CJ, Price, LH. Intranasal oxytocin in obsessive-compulsive disorder. Biol Psychiatry. 1996;40:547–549.CrossRefGoogle ScholarPubMed
9.Epperson, CN, Brown, RM, Price, LH. Obsessive compulsive disorder during pregnancy and the puerperium. Presented at the Annual Meeting of the American Psychiatric Association; May 1995; Miami, Fla. Abstract #NR112.Google Scholar
10.Drago, FC, Caklwell, JD, Pederson, CA, Continella, G, Scapagnini, V, Prange, AJ. Dopamine neurotransmission in the nucleus accumbens may be involved in oxytocin-enhanced grooming behavior of the rat. Pharmacol Biochem Behav. 1986;24:1185–1188.Google Scholar
11.McDougle, CJ, Goodman, WK, Leckman, JF, Lee, NC, Heninger, GR, Price, LH. Haloperidol addition in fluvoxamine-refractory obsessive compulsive disorder: a double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry. 1994;51:302–308.Google Scholar
12.Jacobsen, FM. Risperidone in the treatment of affective illness and obsessive-compulsive disorder. J Clin Psychiatry. 1995;56:423–429.Google Scholar
13.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Associaton; 1994:618–621.Google Scholar
14.Endicott, J Sr. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry. 1978;35:837–844.Google Scholar
15.Winchel, RM, Jones, JS, Molcho, A, Parsons, B, Stanley, B, Stanley, M. The Psychiatric Institute Trichotillomania Scale (PITS). Psychopharmacol Bull. 1992;28:463–476.Google Scholar
16.Goodman, WK, Price, LH, Rasmussen, SA, et al.The Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Part I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46:1006–1011.Google Scholar
17.US Department of Health, Education and Welfare. ECDEU Assessment Manual for Psychopharmacology. Washington, DC: US Department of Health, Education and Welfare; 1976. Publication 76–338.Google Scholar
18.Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62.Google Scholar
19.Hamilton, MA. Diagnosis and rating of anxiety. Br J Psychiatry. 1969;3:76–79.Google Scholar
20.North, WG, LaRochelle, FT, Haldar, J, Sawyer, WH, Valtin, H. Characterization of an antiserum used in a radioimmunoassay for arginine-vasopressin: implications for reference standards. Endocrinology. 1978;103:1976–1984.Google Scholar