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Plasma redox and inflammatory patterns during major depressive episodes: a cross-sectional investigation in elderly patients with mood disorders

Published online by Cambridge University Press:  19 May 2020

Barbara Carpita Open the ORCID record for Barbara Carpita [Opens in a new window] ,
Laura Betti ,
Lionella Palego ,
Natalia Bartolommei ,
Lucia Chico ,
Livia Pasquali ,
Gabriele Siciliano ,
Fabio Monzani ,
Riccardo Franchi  and
Sara Rogani
...Show all authors
Barbara Carpita*
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Laura Betti
Affiliation:
Department of Pharmacy, University of Pisa, Pisa, Italy
Lionella Palego
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Natalia Bartolommei
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Lucia Chico
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Livia Pasquali
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Gabriele Siciliano
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Fabio Monzani
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Riccardo Franchi
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Sara Rogani
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Federico Mucci
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Camilla Elefante
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Lorenzo Lattanzi
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Donatella Marazziti
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Gino Giannaccini
Affiliation:
Department of Pharmacy, University of Pisa, Pisa, Italy
Liliana Dell’Osso
Affiliation:
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
*
Barbara Carpita, MD Email: barbara.carpita1986@gmail.com
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Abstract

Background

While both depression and aging have been associated with oxidative stress and impaired immune response, little is known about redox patterns in elderly depressed subjects. This study investigates the relationship between redox/inflammatory patterns and depression in a sample of elderly adults.

Methods

The plasma levels of the advanced products of protein oxidation (AOPP), catalase (CAT), ferric reducing antioxidant power (FRAP), glutathione transferase (GST), interleukin 6 (IL-6), superoxide dismutase (SOD), total thiols (TT), and uric acid (UA) were evaluated in 30 patients with mood disorders with a current depressive episode (depressed patients, DP) as well as in 30 healthy controls (HC) aged 65 years and over. Subjects were assessed with the Hamilton Depression Rating Scale (HAM-D), the Hamilton Rating Scale for Anxiety (HAM-A), the Geriatric Depression Rating Scale (GDS), the Scale for Suicide Ideation (SSI), the Reason for Living Inventory (RFL), the Activities of Daily Living (ADL), and the Instrumental Activity of Daily Living (IADL).

Results

DP showed higher levels than HC of AOPP and IL-6, while displaying lower levels of FRAP, TT, and CAT. In the DP group, specific correlations were found among biochemical parameters. SOD, FRAP, UA, and TT levels were also significantly related to psychometric scale scores.

Conclusion

Specific alterations of redox systems are detectable among elderly DP.

Keywords

Depressiongeriatricbiochemical markersantioxidative systemsbiological psychiatry
Type
Original Research
Information
CNS Spectrums , Volume 26 , Issue 4 , August 2021 , pp. 416 - 426
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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Footnotes

Barbara Carpita and Laura Betti contributed equally to the work. Gino Giannaccini and Liliana Dell’Osso contributed equally to the work.

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