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Recognizing and Effectively Treating Depression

Published online by Cambridge University Press:  07 November 2014

Abstract

In 2004, more people died in Europe from suicide than from road accidents. The lifetime prevalence of major depression is 20% for women and 10% for men. Depression is a leading cause of disability and decreased quality of life. In spite of this, numerous studies have shown that only ~50% of depressed patients are recognized as such in primary care. In a recent international survey of everyday management of depression we observed that only ~15% of patients became symptom-free following treatment. In spite of this low level of remission primary care physicians and psychiatrist only rarely increased the dose of antidepressant or switched to another medication as unanimously recommended by different guidelines. Numerous studies have demonstrated the importance of maintaining treatment for ≥6 months after remission is obtained in order to prevent relapse and recurrence. However, a recent study reported that only 19% of a cohort of patients in primary care continued treatment for 6 months as recommended. Antidepressants can be very effective but only when used correctly at adequate doses and for a sufficient duration. Although new improved antidepressants are obviously desirable, a greater recognition of depression and its treatment by the correct use of currently available antidepressant drugs could greatly improve the management of this major public health problem.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2008

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References

1. Murphy, JM, Laird, NM, Monson, RR, Sobol, AM, Leighton, AH. A 40-Year Perspective on the Prevalence of Depression. The Stirling County Study. Arch Gen Psychiatry. 2000;57:209215.CrossRefGoogle ScholarPubMed
2. Weissman, MM, Bland, RC, Canino, GJ, et al. Cross national epidemiology of major depression and bipolar disorder. JAMA. 1996; 276:293299.CrossRefGoogle ScholarPubMed
3. Fink, P, Sorensen, L, Engberg, M, Holm, M, Munk-Jørgensen, P. Somatization in primary care. Prevalence, health care utilization, and general practitioner recognition. Psychosomatics. 1999;40:330338.CrossRefGoogle ScholarPubMed
4. Guze, SB, Robins, E. Suicide and primary affective disorders. Br J Psychiatry. 1970;117:437438.CrossRefGoogle ScholarPubMed
5. Druss, BG, Hoff, RA, Rosenheck, RA. Underuse of antidepressants in major depression: prevalence and correlates in a national sample of young adults. J Clin Psychiatry. 2000;61:234237.CrossRefGoogle Scholar
6. Young, AS, Klap, R, Sherbourne, CD, Wells, KB. The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psychiatry. 2001;58:5561.CrossRefGoogle ScholarPubMed
7. Katz, SJ, Kessler, RC, Lin, E, Wells, KB. Medication management of depression in the United States and Ontario. J Gen Intern Med. 1998;13:7785.CrossRefGoogle ScholarPubMed
8. Sirey, JA, Bruce, ML, Alexopoulos, GS, Perlick, DA, Friedman, SJ, Meyers, BS. Stigma as a barrier to recovery. Perceived stigma and patient-rated severity of illness as predictors of antidepressant drug adherence. Psychiatr Serv. 2001;52:16151620.CrossRefGoogle ScholarPubMed
9. Hirschfeld, RM, Keller, MB, Panico, S, et al. The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA. 1997;277:333340.CrossRefGoogle ScholarPubMed
10. Lépine, JP, Gastpar, M, Mendlewicz, J, Tylee, A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol. 1997;12:1929.CrossRefGoogle ScholarPubMed
11. Lecrubier, Y, Hergueta, T. Differences between prescription and consumption of antidepressants and anxiolytics. Int Clin Psychopharmacol. 1998;13(Suppl 2):711.Google ScholarPubMed
12. Nierenberg, AA, Keefe, BR, Leslie, VC, et al. Residual symptoms in depressed patients who respond acutely to fluoxetine. J Clin Psychiatry. 1999;60:221225.CrossRefGoogle ScholarPubMed
13. Paykel, ES, Ramana, R, Cooper, Z, Hayhurst, H, Kerr, J, Barocka, A. Residual symptoms after partial remission: an important outcome in depression. Psychol Med. 1995; 25:11711180.CrossRefGoogle ScholarPubMed
14. ES, Paykel. Remission and residual symptomatology in major depression. Psychopathology. 1998;31:514.Google Scholar
15. Anderson, IM, Nutt, DJ, Deakin, JF. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2000;14:320.CrossRefGoogle ScholarPubMed
16. Management of depression in primary and secondary care, NICE guidance, 2004. Available at: http://guidance.nice.org.uk/CG23. Accessed: June 13, 2008.Google Scholar
17. American Psychiatric Association Practice guidelines for the treatment of patients with major depressive disorder, Second Edition, 2006. Available at: www.psychiatryonline.com/pracGuide/pracGuideTopic_7.aspx. Accessed: June 13, 2008.Google Scholar
18. Sood, N, Treglia, M, Obenchain, RL, Dulisse, B, Melfi, CA, Croghan, TW. Determinants of antidepressant treatment outcome. Am J Manag Care. 2000;6:13271336.Google ScholarPubMed
19. Hunot, VM, Horne, R, Leese, MN, Churchill, RC. A cohort study of adherence to antidepressants in primary care: The influence of antidepressant concerns and treatment preferences. Prim Care Companion J Clin Psychiatry. 2007;9:9199.CrossRefGoogle ScholarPubMed
20. Lecrubier, Y, W-M, Bahk, de Matos, J, Briley, M. The Management of Depression—An international naturalistic survey. Int J Psychiatr Clin Pract. In press.Google Scholar
21. Royal Australian College of General Practitioners Guidelines for Prescribing Benzodiazepines, 2000. Available at: www.racgp.org.au/guidelines/benzodiazepines#guidelines. Accessed: June 2008.Google Scholar
22. Schrader, GD, Gibbs, A, Harcourt, RG. An outpatient survey of antidepressant prescription habits. Aust N Z J Psychiatry. 1986;20:487491.CrossRefGoogle ScholarPubMed
23. Fava, M, Rush, AJ, Trivedi, MH, et al. Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. Psychiatr Clin North Am. 2003;26:457494.CrossRefGoogle ScholarPubMed