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Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts

Published online by Cambridge University Press:  14 August 2017

Amy Krain Roy ,
Randi Bennett ,
Jonathan Posner ,
Leslie Hulvershorn ,
F. Xavier Castellanos  and
Rachel G. Klein
Amy Krain Roy*
Affiliation:
Fordham University New York University Langone School of Medicine
Randi Bennett
Affiliation:
Fordham University
Jonathan Posner
Affiliation:
Columbia University College of Physicians and Surgeons New York State Psychiatric Institute
Leslie Hulvershorn
Affiliation:
Indiana University School of Medicine
F. Xavier Castellanos
Affiliation:
New York University Langone School of Medicine
Rachel G. Klein
Affiliation:
New York University Langone School of Medicine
*
Address correspondence and reprint requests to: Amy Krain Roy, Dealy Hall 418, Fordham University, 441 East Fordham Road, Bronx, NY 10458; E-mail: aroy3@fordham.edu.
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Abstract

Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO.

Type
Regular Articles
Information
Development and Psychopathology , Volume 30 , Issue 2 , May 2018 , pp. 571 - 579
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

We thank Aleta Angelosante, Vasco Lopes, and Sheina Godovich, as well as our participants and their families for their contributions to this research. This work was supported by a Brain and Behavior Research Foundation (previously NARSAD) Young Investigator Award (to A.K.R.), Grant R01MH091140 from the National Institute of Mental Health (A.K.R., Principal Investigator), a grant from the Seevak Family Foundation (R.G.K., Principal Investigator), and an AACAP Pilot Research Award for Junior Faculty and Child and Adolescent Psychiatry Residents, supported by the Elaine Schlosser Lewis Fund (to L.H.).

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