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Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation

Published online by Cambridge University Press:  30 September 2016

Renaud Massart ,
Zsofia Nemoda ,
Matthew J. Suderman ,
Sheila Sutti ,
Angela M. Ruggiero ,
Amanda M. Dettmer ,
Stephen J. Suomi  and
Moshe Szyf
Renaud Massart
Affiliation:
McGill University
Zsofia Nemoda
Affiliation:
McGill University
Matthew J. Suderman
Affiliation:
McGill University
Sheila Sutti
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Angela M. Ruggiero
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Amanda M. Dettmer
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Stephen J. Suomi*
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Moshe Szyf*
Affiliation:
McGill University
*
Address correspondence and reprint requests to: Stephen J. Suomi, Laboratory of Comparative Ethology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7971; E-mail: suomis@lce.nichd.nih.gov; or Moshe Szyf, Department of Pharmacology and Therapeutics, McGill University, 3655 Promonade Sir William Osler, Montreal, QC H3G Y6, Canada; E-mail: moshe.szyf@mcgill.ca.
Address correspondence and reprint requests to: Stephen J. Suomi, Laboratory of Comparative Ethology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7971; E-mail: suomis@lce.nichd.nih.gov; or Moshe Szyf, Department of Pharmacology and Therapeutics, McGill University, 3655 Promonade Sir William Osler, Montreal, QC H3G Y6, Canada; E-mail: moshe.szyf@mcgill.ca.
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Abstract

Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex.

Type
Special Section Articles
Information
Development and Psychopathology , Volume 28 , Special Issue 4pt2: Epigenetics: Development, Psychopathology, Resilience, and Preventive Intervention , November 2016 , pp. 1259 - 1272
Copyright
Copyright © Cambridge University Press 2016 

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