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Adenovirus type 8 keratoconjunctivitis – an outbreak and its treatment with topical human fibroblast interferon

Published online by Cambridge University Press:  19 October 2009

Sheena Reilly ,
B. J. Dhillon ,
Kamona M. Nkanza ,
Annette M. D'Souza ,
N. Taylor ,
Sandra J. Hobbs ,
A Freke  and
A. P. C. H. Roome
Sheena Reilly
Affiliation:
Department of Microbiology and Public Health Laboratory, Derriford Hospital, Plymouth PL6 8DH
B. J. Dhillon
Affiliation:
Royal Eye Infirmary, Apsley Road, Plymouth PL4 6PL
Kamona M. Nkanza
Affiliation:
Royal Eye Infirmary, Apsley Road, Plymouth PL4 6PL
Annette M. D'Souza
Affiliation:
Royal Eye Infirmary, Apsley Road, Plymouth PL4 6PL
N. Taylor
Affiliation:
Royal Eye Infirmary, Apsley Road, Plymouth PL4 6PL
Sandra J. Hobbs
Affiliation:
Joint Regional Public Health and District Virology Laboratory, Myrtle Road, Kingsdown, Bristol BS2 8EL
A Freke
Affiliation:
Joint Regional Public Health and District Virology Laboratory, Myrtle Road, Kingsdown, Bristol BS2 8EL
A. P. C. H. Roome
Affiliation:
Joint Regional Public Health and District Virology Laboratory, Myrtle Road, Kingsdown, Bristol BS2 8EL
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Summary

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An outbreak of keratoconjunctivitis is described which involved at least 186 people; adenovirus type 8 was identified in 50 of the cases. Topical human fibroblast interferon was assessed in a double-blind, placebo-controlled study in which 34 patients participated. Seventeen of the 34 trial patients yielded adenovirus type 8; three were infected with adenovirus type 7. The outbreak was curtailed by control of infection measures: principally careful hand-washing by medical personnel between cases and by discouraging attendance of new cases at the Eye Infirmary. Consequently the trial numbers are small. In addition there was a wide interpatient variation in the severity of infection. Therefore it was not possible to make any statistically valid conclusions concerning the recovery rate of patients receiving interferon or placebo.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 557 - 575
Copyright
Copyright © Cambridge University Press 1986

References

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