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The antigenic activity of some poliomyelitis vaccines used in the United Kingdom in 1958

Published online by Cambridge University Press:  15 May 2009

E. J. C. Kendall ,
R. L. Vollum ,
T. S. L. Beswick ,
Ann Miller  and
J. O'H. Tobin
E. J. C. Kendall
Affiliation:
Medical Officer, Epsom College, Epsom
R. L. Vollum
Affiliation:
Public Health Laboratory, Oxford
T. S. L. Beswick
Affiliation:
Biological Standards Control Laboratory, Medical Research Council Laboratories, Hampstead, N.W.3
Ann Miller
Affiliation:
Biological Standards Control Laboratory, Medical Research Council Laboratories, Hampstead, N.W.3
J. O'H. Tobin
Affiliation:
Biological Standards Control Laboratory, Medical Research Council Laboratories, Hampstead, N.W.3
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The potency in man of eight different commercial vaccines and an experimental vaccine, as judged by the antibody response after the primary course of two injections and after a booster dose 9–12 months later, was compared. All the vaccines produced good responses to Types 2 and 3 but some were less satisfactory for Type 1. The relation of potency to protection in man is discussed and the use of one of the vaccines as a minimum standard for this country is suggested.

Type
Research Article
Information
Journal of Hygiene , Volume 58 , Issue 4 , December 1960 , pp. 399 - 408
Copyright
Copyright © Cambridge University Press 1960

References

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