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Duration of Passive Immunity. Part III

Published online by Cambridge University Press:  15 May 2009

A. T. Glenny  and
Barbara E. Hopkins
A. T. Glenny
Affiliation:
(Wellcome Physiological Research Laboratories, Beckenham, Kent.)
Barbara E. Hopkins
Affiliation:
(Wellcome Physiological Research Laboratories, Beckenham, Kent.)
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1. The course of disappearance of passive immunity in rabbits injected with diphtheria antitoxin obtained from goats, men, guinea-pigs and cows, consists of the same three phases that follow the injection of horse serum.

2. The rabbits examined were more responsive to goat, human and guinea-pig serum than to horse and cow serum.

3. The course of disappearance of passive immunity in rabbits, horses and guinea-pigs injected with homologous antitoxin, consists of Phases A and B only, and Phase B is far slower than when heterologous serum is injected into rabbits.

4. Sheep and goats eliminate antitoxin obtained from a horse at a very slow rate, and Phase C is hardly detectable.

5. Natural immunity of horses to diphtheria toxin is gradually acquired by a number of increasing responses to external stimuli.

Type
Research Article
Information
Journal of Hygiene , Volume 22 , Issue 1 , October 1923 , pp. 37 - 51
Copyright
Copyright © Cambridge University Press 1923

References

REFERENCES

Glenny, and Allen, . 1921. Journ. Path. and Bacteriol. XXIV. 61.CrossRefGoogle Scholar
Hartley, and Hartley, . 1922. Journ. Path. and Bacteriol. XXV. 462Google Scholar