Hostname: page-component-848d4c4894-v5vhk Total loading time: 0 Render date: 2024-06-13T14:14:11.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Bradykinesia In Patients With Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  16 April 2020

M. Pasquini ,
G. Fabbrini ,
G. Moretti ,
I. Berardelli ,
G. Mandarelli ,
R. Delle Chiaie ,
C. Leone ,
M. Biondi  and
A. Berardelli
M. Pasquini
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
G. Fabbrini
Affiliation:
Department of Neurological Sciences, Sapienza University of Rome, Neuromed Institute, Viale dell’Università 30, 00185Rome, Italy
G. Moretti
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
I. Berardelli
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
G. Mandarelli
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
R. Delle Chiaie
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
C. Leone
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
M. Biondi
Affiliation:
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
A. Berardelli*
Affiliation:
Department of Neurological Sciences, Sapienza University of Rome, Neuromed Institute, Viale dell’Università 30, 00185Rome, Italy
*
*Corresponding author. Tel.: +39 0649914700; fax: +39 0649914700. E-mail address: alfredo.berardelli@uniroma1.it (A. Berardelli).
Get access

Abstract

Objective

To investigate the frequency of bradykinesia in patients with obsessive-compulsive disorder (OCD) and to see whether patients with OCD who also have bradykinesia display distinctive neuropsychological and neuropsychiatric features.

Methods

We studied 23 antipsychotic-free patients with OCD and 13 healthy controls. Bradykinesia was assessed with section III of the Unified Parkinson Disease Rating Scale. The Wechsler Adult Intelligent Scales-Revised (WAIS-R) was used to assess the Full Scale IQ and to measure visuospatial, visuoconstructional ability and psychomotor speed/mental slowness.

Results

Of the 23 patients with OCD studied, 8 (34%) had mild symptoms of bradykinesia. No relationship was found between bradykinesia and the sociodemographic variables assessed but this motor symptom was significantly associated with the severity of compulsions. Patients with bradykinesia differed from those without: they had a higher frequency of repeating compulsions, and lower IQ scores, performance scores, and WAIS-R subtest scores for similarities and picture completion. No significant differences were found between patients without bradykinesia and healthy controls in any test.

Conclusions

Clinical assessment of motor symptoms in adult patients with OCD often discloses mild bradykinesia sometimes associated with repeating compulsions and poor WAIS-R performance scores.

Keywords

Obsessive-compulsive disorderBradykinesiaBasal ganglia
Type
Obsessive-Compulsive Disorders
Information
European Psychiatry , Volume 25 , Issue 7 , November 2010 , pp. 378 - 381
Copyright
Copyright © Elsevier Masson SAS 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berardelli, A., Rothwell, J.C., Hallett, M., Thompson, P.D., Manfredi, M., Marsden, C.D.The pathophysiology of primary dystonia. Brain 1998; 121: 1195–1212.CrossRefGoogle ScholarPubMed
Berardelli, A., Rothwell, J.C., Thompson, P.D., Hallett, M.Pathophysiology of bradykinesia in Parkinson's disease. Brain 2001; 124: 2131–2146.CrossRefGoogle ScholarPubMed
Bucci, P., Galderisi, S., Catapano, F., Di Benedetto, R., Piegari, G., Mucci, A.et al.Neurocognitive indices of executive hypercontrol in obsessive-compulsive disorder. Acta Psychiatr Scand 2007; 115: 380–387.CrossRefGoogle ScholarPubMed
Cath, D.C., Spinhoven, P., Hoogduin, C.A., Landman, A.D., van Woerkom, T.C., van de Wetering, B.J.Repetitive behaviors in Tourette's syndrome and OCD with and without tics: what are the differences?. Psychiatry Res 2001; 101: 171–185.CrossRefGoogle ScholarPubMed
Fahn, S., Elton, R.L.UPDRS Development Committee. Unified Parkinson's disease rating scale. Fahn, S., Marsden, C.D., Calne, D.B., Goldstein, M., Recent Developments in Parkinson's Disease Florham Park, NJ: Macmillan; 1987. 153–163.Google Scholar
First, MB, Spitzer, RL, Gibbon, M, Williams, JB.Structured clinical interview for DSM-IV axis I disorders, clinical version (SCID-I CV). (Italian version by Mazzi, F, Morosini, P, de Girolamo, Get al.). Florence, Italy: Organizzazioni Speciali, 2000.Google Scholar
Goodman, W.K., Price, L.H., Rasmussen, S.A.et al.The Yale-Brown obsessive-compulsive scale I. Development, use and reliability. Arch Gen Psychiatry 1989; 46: 1012–1016.CrossRefGoogle ScholarPubMed
Hamilton, M.The assessment of anxiety states by rating. Br J Med Psychol 1959; 32: 50–55.CrossRefGoogle ScholarPubMed
Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62.CrossRefGoogle ScholarPubMed
Hymas, N., Lees, A., Bolton, D., Epps, K., Head, D.The neurology of obsessional slowness. Brain 1991; 114: 2203–2233.CrossRefGoogle ScholarPubMed
Mavrogiorgou, P., Mergl, R., Tigges, P., El Husseini, J., Schröter, A., Juckel, G.et al.Kinematic analysis of handwriting movements in patients with obsessive-compulsive disorder. J Neurol Neurosurg Psychiatry 2001; 70: 605–612.CrossRefGoogle ScholarPubMed
Mergl, R., Mavrogiorgou, P., Juckel, G., Zaudig, M., Hegerl, U.Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder. Psychopharmacology (Berl) 2004; 171: 179–185.CrossRefGoogle ScholarPubMed
Mergl, R., Mavrogiorgou, P., Juckel, G., Zaudig, M., Hegerl, U.Can a subgroup of OCD patients with motor abnormalities and poor therapeutic response be identified?. Psychopharmacology (Berl) 2005; 179: 826–837.CrossRefGoogle ScholarPubMed
Moritz, S., Kloss, M., von Eckstaedt, F.V., Jelinek, L.Comparable performance of patients with obsessive-compulsive disorder (OCD) and healthy controls for verbal and nonverbal memory accuracy and confidence: Time to forget the forgetfulness hypothesis of OCD?. Psychiatry Res 2009; 166: 247–253.CrossRefGoogle ScholarPubMed
Moritz, S., Ruhe, C., Jelinek, L., Naber, D.No deficits in nonverbal memory, metamemory and internal as well as external source memory in obsessive-compulsive disorder (OCD). Behav Res Ther 2009; 47: 308–315.CrossRefGoogle Scholar
Nakao, T., Nakagawa, A., Nakatani, E., Nabeyama, M., Sanematsu, H., Yoshiura, T.et al.Working memory dysfunction in obsessive-compulsive disorder: A neuropsychological and functional MRI study. J Psychiatr Res 43(8)2009 784–791.CrossRefGoogle ScholarPubMed
Pasquini, M., Fabbrini, G., Berardelli, I., Bonifati, V., Biondi, M., Berardelli, A.Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. Psychiatry Res 2008; 161: 109–111.CrossRefGoogle Scholar
Penades, R., Catalan, R., Andres, S., Salamero, M., Gasto, C.Executive function and non verbal memory in obsessive-compulsive disorder. Psychiatry Res 2005; 133: 81–90.CrossRefGoogle Scholar
Purcell, R., Maruff, P., Kyrios, M., Pantelis, C.Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal functions. Biol Psychiatry 1998; 43: 348–357.CrossRefGoogle Scholar
Roth, R.M., Baribeau, J., Milovan, D.L., O’Connor, K.Speed and accuracy on tests of executive function in obsessive-compulsive disorder. Brain Cogn 2004; 54: 263–265.CrossRefGoogle ScholarPubMed
Simpson, H.B., Rosen, W., Huppert, J.D., Lin, S.H., Foa, E.B., Liebowitz, M.R.Are there reliable neuropsychological deficits in obsessive-compulsive disorder?. J Psychiatr Res 2006; 40: 247–257.CrossRefGoogle ScholarPubMed
Thompson, P.D., Berardelli, A., Rothwell, J.C., Day, B.L., Dick, J.P., Benecke, R.et al.The coexistence of bradykinesia and chorea in Huntington's disease and its implications for theories of basal ganglia control of movement. Brain 1988; 111: 223–244.CrossRefGoogle ScholarPubMed
Wechsler, D.Wechsler memory scale-revised. San Antonio: Psychological Corporation; 1987.Google Scholar
Submit a response

Comments

No Comments have been published for this article.