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Cocaine use and Opioid Withdrawal Syndrome

Published online by Cambridge University Press:  16 April 2020

JC Perez de los Cobos ,
JJ Lopez-Ibor Jr ,
P Sopelana  and
M Castañeda
JC Perez de los Cobos
Affiliation:
Unidad de Toxicomanías, Programa Sant Pau-Citran, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Ma Claret, 167, 08025, Barcelona, Spain
JJ Lopez-Ibor Jr
Affiliation:
Unidad de Toxicomanías, Programa Sant Pau-Citran, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Ma Claret, 167, 08025, Barcelona, Spain
P Sopelana
Affiliation:
Unidad de Toxicomanías, Programa Sant Pau-Citran, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Ma Claret, 167, 08025, Barcelona, Spain
M Castañeda
Affiliation:
Unidad de Toxicomanías, Programa Sant Pau-Citran, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Ma Claret, 167, 08025, Barcelona, Spain
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Summary

The present study was carried out in 2 successive phases. In the first, 91 inpatients admitted for opioid dependence were evaluated. All were treated with α2-agonists during the withdrawal period. Shortly after admission, a urine sample was taken and analyzed (EMIT and GC/MS). The presence of the cocaine metabolite benzoilecgonine in urine was a predictor of dropout probability during hospitalization (P < 0.01). A second study on a sample of 612 inpatients later admitted for similar reasons was carried out according to a simpler protocol (using only EMIT) in order to replicate the previous results. Again, the presence of benzoilecgonine in urine indicated dropout probability (P = 0.00004). Thus, the use of cocaine prior to admission for a treatment of opiate withdrawal syndrome with α2-agonists seems to predict therapeutic failure.

Keywords

cocaineopioid withdrawalα2-agonists
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 2 , 1991 , pp. 89 - 92
Copyright
Copyright © Elsevier, Paris 1991

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