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A disorder in executive functions crosses traditional diagnostic borders of the schizophrenia-bipolar spectrum

Published online by Cambridge University Press:  01 September 2022

I. Szendi Md Habil ,
P. Pajkossy ,
A. Bagi ,
M. Marián ,
Á. Szőllősi  and
M. Racsmány
I. Szendi Md Habil*
Affiliation:
Kiskunhalas Semmelweis Hospital, University Teaching Hospital, Psychiatry Unit, Kiskunhalas, Hungary
P. Pajkossy
Affiliation:
Research Centre for Natural Sciences, Institute Of Cognitive Neuroscience And Psychology, Budapest, Hungary
A. Bagi
Affiliation:
University of Szeged, Department Of Psychiatry, Szeged, Hungary
M. Marián
Affiliation:
Budapest University of Technology and Economics, Department Of Cognitive Science, Budapest, Hungary
Á. Szőllősi
Affiliation:
Research Centre for Natural Sciences, Institute Of Cognitive Neuroscience And Psychology, Budapest, Hungary Budapest University of Technology and Economics, Department Of Cognitive Science, Budapest, Hungary
M. Racsmány
Affiliation:
Research Centre for Natural Sciences, Institute Of Cognitive Neuroscience And Psychology, Budapest, Hungary Budapest University of Technology and Economics, Department Of Cognitive Science, Budapest, Hungary
*
*Corresponding author.

Abstract

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Introduction

Our series of studies in the spectrum of psychosis (schizophrenia, bipolar affective disorder, schizoaffective disorder) is based on the concept of the RDoC system.

Objectives

In this study, we were interested in knowing whether cross-diagnostic disturbances in cognitive functions can be found in the spectrum and whether they predict clinical symptoms.

Methods

In the study, N = 66 schizophrenic (M = 38.2 ± 9.37 years, 26 women), N = 30 bipolar (M = 47.4 ± 9.35 years, 19 women), N = 33 schizoaffective (M = 39.8 years± 11.3 years, 21 women) and N = 28 healthy subjects (M = 36.5 ± 9.9 years, 14 women) participated. All subjects underwent the Wisconsin Card Sorting Test (WCST), Raven Test, Digit Span Test, Visual Patterns Test, Letter and Semantic Fluency tests, Metaphor and Irony Comprehension, Directed Forgetting, Stop Signal Test, and Lexical Decision Task. In addition, symptom rating scales were administered (PANSS, SANS, YMRS, MADRS).

Results

Based on our results, the performance of the WCST-deficient group lagged behind the WCST-non-deficient group and the healthy control group in most executive control tests. Importantly, this effect was independent of diagnosis, so it appeared in all three patient groups. Members of the deficit group had a higher rate of negative symptoms.

Conclusions

Disruption of executive functions is a transdiagnostic feature of the schizophrenia-bipolar spectrum, which could be associated with any diagnosis.

Disclosure

No significant relationships.

Keywords

TransdiagnosticRDoCExecutive functionsWCST
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S153
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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