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EPA-0691 – Pharmacovigilance in a Psychiatric Hospital: Adverse Drug Reactions in One Half to One Third of Elderly or Chronically ill Inpatients

Published online by Cambridge University Press:  15 April 2020

K. Sander
Affiliation:
Versorgungsforschung Kliniken des Bezirks Oberbayern, kbo-Inn-Salzach-Klinikum gemeinnützige GmbH, Wasserburg am Inn, Germany
E. Förster
Affiliation:
Apotheke, kbo-Isar-Amper-Klinikum München Ost gemeinnützige GmbH, Haar, Germany
G. Laux
Affiliation:
Ärztlicher Direktor, kbo-Inn-Salzach-Klinikum gemeinnützige GmbH, Wasserburg am Inn, Germany

Abstract

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Introduction:

Knowledge of drug prescription is essential for pharmacovigilance, i. e. for classifying adverse drug reactions (ADR) in clinical routine and for methods of their elimination and prevention.

Objectives:

Since the frequency of ADR is correlated with age, multi-morbidity and polypharmacy, special attention should be given to the medication of elderly or chronically ill patients.

Aims:

To determine the rate of all kinds of ADR inpatient data (number, gender, age, and psychiatric diagnoses), drug prescriptions and occurrences of ADR were surveyed.

Methods:

Once in a week for a period of six weeks data from all inpatients of an open station of each of the departments social psychiatry and geriatric psychiatry of the kbo-Inn-Salzach-Klinikum gemeinnützigen GmbH were determined.

Results:

The 34 inpatients of geriatric psychiatry were on average 75 years old with on average eight prescribed drugs. Leading diagnosis was recurrent depression’ (17%); leading prescribed agent was sertraline (13%). In 55% of cases ADR occurred, mostly eliminated by medicinal counteractions (34%).

The 54 inpatients of social psychiatry were on average 41 years old with on average four prescribed drugs. Leading diagnosis was paranoid schizophrenia (24%); leading prescribed agent was risperidone (14%). In 36% of cases ADR occurred, mostly eliminated by stopping medication and medicinal counteractions (each 31%).

Conclusions:

In general, new drugs were prescribed in a cautious dose-regime. Clozapine was still of high relevance. Drug prescriptions were age specific as was the occurrence of ADR. Although ADR occurrence was high (55% and 36%), severe cardiac and circulatory troubles were relatively rare.

Type
EPW37 – Psychopharmacology and Pharmacoeconomics 2
Copyright
Copyright © European Psychiatric Association 2014
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