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EPOS - sample characteristics, transition rates and psychopathological predictors

Published online by Cambridge University Press:  16 April 2020

S. Ruhrmann ,
R.K.R. Salokangas ,
D. Linzen ,
M. Birchwood ,
G. Juckel ,
F. Schultze-Lutter ,
H. Graf ,
V. Reventlow ,
A. Morrison  and
S. Lewis
...Show all authors
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
R.K.R. Salokangas
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
D. Linzen
Affiliation:
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
School of Psychology and EDIT, University of Birmingham, Birmingham, United Kingdom
G. Juckel
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bochum, Bochum, Germany
F. Schultze-Lutter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
H. Graf
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
V. Reventlow
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
A. Morrison
Affiliation:
Department of Psychology, University of Manchester, Manchester, United Kingdom
S. Lewis
Affiliation:
Department of Psychology, University of Manchester, Manchester, United Kingdom
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Abstract

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Background and Aims

A main objective of EPOS is to provide a valid multifactorial model for the prediction of psychosis. One major element of such a model should be the clinical state.

Methods

In a European multicentre study, persons fulfilling clinical criteria thought to indicate an increased risk for psychosis (PAR) were assessed amongst others with different psychopathological instruments covering the whole spectrum from basic symptoms to frank psychotic symptoms. Inclusion criteria comprised attenuated positive symptoms (APS), brief limited intermittent psychotic symptoms (BLIPS), cognitive basic symptoms (CogDis) and a combination of family risk and reduced functioning (S&T).

Results

246 PAR were included into the study, mostly by APS or CogDis. Analysis of demographical data showed a high amount of functional impairment, resulting e.g. in low mean GAF scores (51.0 ± 11.8 SD), and of non-psychotic axis-I disorders. In September 2006, the hazard rate for a conversion to psychosis was 15.3 at 12 and 20.0 at 18 months after baseline assessment. According to the inclusion criteria, the highest rate of conversion was observed among PAR with BLIPS. On a dimensional level, a low GAF score was among the best predictors of conversion.

Conclusions

The transition rates of EPOS were in line with recent studies. A first analysis of clinical data supports the notion that the functional state should be an inherent part of any set of clinical risk criteria. Further analysis will consider the contribution of single symptoms or symptom combinations and the impact of symptom duration.

Type
S42. Symposium: EPOS-First Results of the Completed Study
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S64
Copyright
Copyright © European Psychiatric Association 2007
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