The subjective well-being has been associated with dropouts of treatment and relapses.

Determine baseline variables associated with a positive evolution in subjective well-being (increase of 20% and ≥10 points in subjective SWN-K). Assess the relationship between SWN-K and compliance of treatment.

Non-interventional, prospective (6 moths) study of a cohort of patients with schizophrenia of schizoaffective disorders who have had a clinical relapse that required a change in therapeutic strategy.

305 patients were included, 288 (94.4%) was the population analyzed and 272 (89.1%) completed the follow-up. 226 (78.5%) of patients have a diagnosis of schizophrenia, the rest were diagnosed of schizoaffective disorder.

Mean total scores in SWN-K were statistically significant in every visit vs. baseline (69.5, 75.5, 77.8 and 80.0). All subscales (social, physical, emotional, mental and self-control) showed a parallel evolution. This progress was associated with compliance according to the evaluations by the psychiatrist, family and patient.

Baseline variables associated to positive response in SWN-K in logistic regression were: gender (female) and depressive symptoms (CDSS).

Progress in SWN-K score was related to compliance. Depressive symptoms and gender are the only variables at baseline associated with positive response in SWN-K.