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Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy?

Published online by Cambridge University Press:  16 April 2020

A. Alciati ,
F. Starace ,
B. Scaramelli ,
M. Campaniello ,
B. Adriani ,
C. Mellado  and
A. Cargnel
A. Alciati
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
F. Starace*
Affiliation:
Consultation Psychiatry Service, Ospedale D. Cotugno, and Institute of Psychiatry, University of Naples, SUN, Italy
B. Scaramelli
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
M. Campaniello
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
B. Adriani
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
C. Mellado
Affiliation:
Dept. of Psychiatry, Ospedale L. Sacco, Milan, Italy
A. Cargnel
Affiliation:
2nd Dept. of Infectious Diseases, Ospedale L. Sacco, Milan, Italy
*
*Correspondence and reprints: Consultation Psychiatry Service, Cotugno Hospital, Via G. Quagliariello, 54, 80131 - Napoli, Italy. E-mail address:fabrizio.starace@tin.it (F. Starace).
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Summary

Purpose.

The aim of this study was to assess the prevalence of current mood disorders in HIV-seropositive patients treated with combined antiretroviral drug therapy including or not protease inhibitors.

Subjects and methods.

A random sample of 90 subjects consecutively attending, between February 1 and July 31, 1998, the outpatient unit of the Second Department of Infectious Diseases of the ‘L. Sacco’ Hospital in Milan was assessed by means of the Structured Clinical Interview for DSMIII-R (SCID) and the Zung Self-Rating Depression Scale (ZSDS).

Results.

Twenty-three-point-three percent of the subjects were classified in CDC stage A, 32.3% in CDC stage B and 44.4% in CDC stage C. A DSMIII-R psychiatric diagnosis of current mood disorder was found in 4.4% of the recruited sample (dysthymia: 2.2%; adjustment disorder with depressed mood: 2.2%).

Conclusions.

Direct and indirect effect of new combination therapies, epidemiological changes in social groups affected by HIV and possible modifications in social perception of people with HIV infection may explain, at least in part, the decreased prevalence of current mood disorders observed in our study as compared to prevalence rates reported in the pre-HAART era.

Keywords

depressionHAARTHIVmood disordersprevalence study
Type
Original Articles
Information
European Psychiatry , Volume 16 , Issue 8 , December 2001 , pp. 491 - 496
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS

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