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Impact of an Intervention of Neuro-cognitive Rehabilitation in Treatment Resistant Schizophrenia (TRS) Compared to Schizophrenia Responder Patients

Published online by Cambridge University Press:  23 March 2020

L. D’Ambrosio ,
E. Prinzivalli ,
N. Oliviero ,
R. Balletta ,
G. Callovini ,
A. Benedetta ,
M.V. Formato ,
S. Lattanzio ,
E. Razzino  and
C. Avagliano
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L. D’Ambrosio
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
E. Prinzivalli
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
N. Oliviero
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
R. Balletta
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
G. Callovini
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
A. Benedetta
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
M.V. Formato
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
S. Lattanzio
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
E. Razzino
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
C. Avagliano
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy
A. de Bartolomeis
Affiliation:
Department of Neuroscience Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy

Abstract

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Introduction

Schizophrenia is a condition with high impact in terms of disability, also because between 30% and 60% affected individuals do not respond to treatment. It has been proposed that cognitive functioning is strongly impaired in schizophrenia and even more in TRS patients. Cognitive dysfunctions are regarded to worsen psychopathology, psychosocial functioning, and overall course of the illness.

Objectives

To investigate the impact of Cognitive Remediation (CR) on psychopathology and psychosocial functioning in TRS vs. schizophrenia responder patients.

Aims

To determine whether a CR intervention could improve functional outcomes in TRS patients.

Methods

We evaluated proximal and distal effects of CR on approximately 20 schizophrenia responders and 20 TRS patients. Patients in each group were randomized to receive CR or not. Patients were assessed in training task performance, neurocognition, functional capacity, symptoms and psychosocial functioning. Evaluations were conducted at baseline, at the end of the 4-month intervention, and at 6-month, 1 and 2 year-follow-ups. The study is still in active recruitment phase.

Results

Both TRS and schizophrenia responder patients exposed to CR exhibited a significant improvement in specific neurocognitive domains, and in psychosocial functioning as assessed by either rating scales (SLOF and PSP) and performance-based measures (UPSA) at the 4-month time-point.

Conclusions

CR improved psychosocial functioning in both group of patients, however, they were more pronounced in TRS patients.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Schizophrenia and other psychotic disorders - Part 3
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S266 - S267
Copyright
Copyright © European Psychiatric Association 2017
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