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Impulsivity and Brain Volume in Patients with Bipolar Disorder type I and Bipolar Disorder Type II

Published online by Cambridge University Press:  23 March 2020

D. Janiri ,
G. Giuseppin ,
E. Spinazzola ,
M. Maggiora  and
G. Sani
G. Giuseppin
Affiliation:
Sapienza University of Rome- Faculty of Medicine and Psychology, NESMOS Department Neurosciences- Mental Health and Sensory Functions, Rome, Italy
E. Spinazzola
Affiliation:
Sapienza University of Rome- Faculty of Medicine and Psychology, NESMOS Department Neurosciences- Mental Health and Sensory Functions, Rome, Italy
M. Maggiora
Affiliation:
Sapienza University of Rome- Faculty of Medicine and Psychology, NESMOS Department Neurosciences- Mental Health and Sensory Functions, Rome, Italy
G. Sani
Affiliation:
Sapienza University of Rome- Faculty of Medicine and Psychology, NESMOS Department Neurosciences- Mental Health and Sensory Functions, Rome, Italy

Abstract

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Introduction

Impulsivity is a key feature of both bipolar disorder (BD) type I (BDI) and type II (BDII).

Objective

Structural neuroimaging studies help clarifying brain mechanisms underpinning the regulation of impulsivity in BDI and BDII.

Aims

To address the question whether grey matter (GM) alterations relate differently with impulsivity in BDI and BDII.

Methods

We assessed 54 euthymic outpatients, diagnosed with BDI (n = 28) or BDII (n = 26) according to DSM-IV-TR criteria. They underwent a 3 T magnetic resonance imaging (MRI) investigation. GM brain volumes were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale (BIS), version 11A, was used to assess trait impulsivity.

Results

BDI and BDII patients present an inverse relationship between impulsivity and GM volume in two cerebral areas: the right cerebellum (right crus I) and the interface between the left angular gyrus and the left inferior parietal cortex (Brodmann Area 39, 7, 40). More specifically, a negative relationship for BPI and a positive relationship for BPII were found in both areas.

Conclusions

Results suggest that the different diagnosis between BDI and BDII could have a significant effect on GM changes according to impulsivity severity and point up the importance of considering the BP subtype distinction in neuroimaging studies on this topic.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Oral communications: Bipolar disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S75
Copyright
Copyright © European Psychiatric Association 2017
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