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Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study

Published online by Cambridge University Press:  01 September 2022

G. Erzin ,
L. Pries ,
S. Dimitrakopoulos ,
I. Ralli ,
L.-A. Xenaki ,
R.F. Soldatos ,
I. Vlachos ,
M. Selakovic ,
S. Foteli  and
I. Kosteletos
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G. Erzin*
Affiliation:
Ankara Dışkapı Training and Research Hospital, Psychiatry, ANKARA, Turkey
L. Pries
Affiliation:
Maastricht University Medical Center, Department Of Psychiatry And Neuropsychology, School For Mental Health And Neuroscience, maastricht, Netherlands
S. Dimitrakopoulos
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
I. Ralli
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
L.-A. Xenaki
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
R.F. Soldatos
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
I. Vlachos
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
M. Selakovic
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
S. Foteli
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
I. Kosteletos
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
N. Nianiakas
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
L. Mantonakis
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
E. Rizos
Affiliation:
National and Kapodistrian University of Athens Medical School, Second Department Of Psychiatry, Athens, Greece
K. Kollias
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
J. Os
Affiliation:
Maastricht University Medical Center, Department Of Psychiatry And Neuropsychology, School For Mental Health And Neuroscience, maastricht, Netherlands
S. Guloksuz
Affiliation:
Maastricht University Medical Center, Department Of Psychiatry And Neuropsychology, School For Mental Health And Neuroscience, maastricht, Netherlands
N. Stefanis
Affiliation:
National and Kapodistrian University of Athens Medical School, Eginition Hospital, First Department Of Psychiatry, Athens, Greece
*
*Corresponding author.

Abstract

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Introduction

Previously, environmental vulnerability for schizophrenia assessed through exposome score for schizophrenia (ES-SCZ) was associated with the risk for psychosis development.

Objectives

The current study aims to investigate the longitudinal association between ES-SCZ and symptom severity in individuals with first episode psychosis (FEP) to understand how environmental exposures affect illness course.

Methods

Baseline and 1-month follow-up assessments were available for 225 individuals with FEP from the Athens FEP Research Study. The Positive and Negative Syndrome Scale (PANSS) was used to measure clinical features. In accordance with previous reports, the ES-SCZ was calculated by summing log-odds weighted environmental exposures (childhood adversities, winter birth, and cannabis use). To model the course of clinical features over time the effects of the ES-SCZ-by-time interaction, ES-SCZ, and time were analyzed with multilevel regression analyses. Age, sex, and education were added as covariates

Results

The analyses of change of PANSS total score over time indicated that clinical features decreased from baseline to the 1-month follow-up assessment. The association between ES-SCZ and PANSS total score were not statistically significant. The analyses of the PANSS total score over time indicated an ES-SCZ-by-time interaction (B = 2.82 [95% CI 0.28; 5.35], P-value = 0.029), meaning the decrease of the PANSS total score over time were dependent on ES-SCZ and individuals with high ES-SCZ showed less improvement

Conclusions

The findings show that the total environmental predisposition to schizophrenia (ES-SCZ) not only increases the risk for psychosis development but may also influences the illness course.

Disclosure

No significant relationships.

Keywords

environmental exposuresclinical featuresexposomePsychosis
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S760
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Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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