Hostname: page-component-848d4c4894-2pzkn Total loading time: 0 Render date: 2024-06-12T16:15:52.287Z Has data issue: false hasContentIssue false

Loss of automatic processes and blunted-affect in depression: a P3 study

Published online by Cambridge University Press:  16 April 2020

A Partiot
Affiliation:
CNRS EP 53 Psychobiologie des Tempéraments à Risques
A Pierson*
Affiliation:
CNRS EP 53 Psychobiologie des Tempéraments à Risques
J Le Houezec
Affiliation:
CNRS URA 654-LENA, Psychophysiologie Cognitive, Hôpital de la Salpêtrière, Pavillon Clérambault, 75651Paris, Cedex 13, France
V Dodin
Affiliation:
CNRS URA 654-LENA, Psychophysiologie Cognitive, Hôpital de la Salpêtrière, Pavillon Clérambault, 75651Paris, Cedex 13, France
B Renault
Affiliation:
CNRS EP 53 Psychobiologie des Tempéraments à Risques
R Jouvent
Affiliation:
CNRS EP 53 Psychobiologie des Tempéraments à Risques
*
*Correspondence and reprints.
Get access

Summary

The P3 components (P3a and P3b) of the event-related potentials have been analysed in sixteen in-patients with a major depressive episode (DSM III-R) according to their subtype - anxious-agitated and impulsive versus retarded and blunted-affect - assuming that these two opposite dimensions of the depressive mood would rely on different physiopathological mechanisms. The P3a component, which indexes automatic cognitive processes, was dramatically decreased in the retarded and blunted-affect group. This suggests that this special type of cognitive dysfunction in depression is rather related to negative symptoms than to depression itself.

Type
Original article
Copyright
Copyright © Elsevier, Paris 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrams, R, Taylor, MA (1978) A rating scale for emotional blunting. Am J Psychiatry 135, 226229Google ScholarPubMed
Ammar, S, Leboyer, M, Bouvard, M, Baruk, P, Lisoprawski, A, Jouvent, R (1989) Transnosological effects of dopaminergic agonists on emotional blunting. The mesolimbic dopamine system: From motivation to action. Malte 25-29 sept 1989. Behav Pharmacol 1, suppl 1, 47Google Scholar
Asberg, M, Traskman, L, Thorèn, Ρ (1976) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 33, 11931197CrossRefGoogle ScholarPubMed
Austin, MP, Ross, M, Murray, C, O'Carroll, REet al (1992) Cognitive function in major depression. J Affective Disord 25, 2129CrossRefGoogle ScholarPubMed
Baribeau-Braun, J, Lesèvre, N (1983) Event-related potential assessment of psychomotor retardation in depressives. Adv Biol Psychiatry 13, 211223CrossRefGoogle Scholar
Blackwood, DRH, Whalley, LJ, Christie, JEet al (1987) Changes in auditory P3 ERP in schizophrenia and depression. Br J Psychiatry 150, 154160CrossRefGoogle ScholarPubMed
Braconnier, A, Bouvard, M, Jouvent, R (1986) L'humeur et le ralentissement chez l'adolescent déprimé. Étude comparative avec une population de déprimés adultes. Psychiatr Psychobiol 3, 214219Google Scholar
Brand, N, Jolles, J (1987) Information processing in depression and anxiety. Psychol Med 17, 145153CrossRefGoogle ScholarPubMed
Bruder, G, Towey, J, Stewart, J, Friedman, D, Erhan, Het al (1989) Event-Related Potentials in typical and atypical depression: P3 latency differences 9th International Conference on Event-Related Potentials of the Brain (EPIC IX) III, 31Google Scholar
Desmedt, JE (1980) P300 in serial tasks: an essential post-decision closure mechanism.In: Motivation, Motor and Sensory Processes of the Brain (Kornhuber, HH, Deecke, L, eds). Prog Brain Res 54, 682686Google Scholar
Desmedt, JE, Debecker, J (1979) Slow potential shifts and decision P350 interactions in tasks with random sequences of near-threshold clicks and finger stimuli delivered at regular intervals. Electroencephalogr Clin Neurophysiol 47, 671679CrossRefGoogle ScholarPubMed
Donchin, E, Coles, GHM (1988) Is the P300 component a manifestation of context updating? Behav Brain Sci 11, 357374CrossRefGoogle Scholar
El Massioui, F, Lesèvre, N (1988) Attention impairment and psychomotor retardation in depressed patients: an event-related potential study. Electroencephalogr Clin Neurophysiol 70, 4655CrossRefGoogle Scholar
Giedke, H, Thier, P, Bolz, J (1981) The relationship between P3 latency and reaction time in depression. Biol Psychol 13, 3149CrossRefGoogle ScholarPubMed
Golinkoff, M, Sweeney, JA (1989) Cognitive impairments in depression. J Affective Disord 17, 105112CrossRefGoogle ScholarPubMed
Goodin, DS, Squires, KC, Henderson, BH, Starr, A (1978) Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephal Clin Neurophysiol 44, 447458CrossRefGoogle ScholarPubMed
Hamilton, MA (1960) Rating scale for depression. J Neurol Neurosurg Psychiatry 23, 5662CrossRefGoogle ScholarPubMed
Iragui, VJ, Kutas, M, Mitchiner, MR, Hillyard, SA (1993) Effects of aging on event-related brain potentials and reaction times in an auditory oddball task. Psychophysiol 30, 1022CrossRefGoogle Scholar
Johnson, R Jr (1986) A triarchic model of P300 Amplitude. Psychophysiol 23, 367384CrossRefGoogle ScholarPubMed
Jouvent, R (1989) Evaluating the affective and cognitive effect of a drug: theoretical and methodological considerations. Arch Gerontol Geriatr suppl 1, 165172Google Scholar
Jouvent, R, Partiot, A, Ammar, S, Pierson, A, Renault, B, Widlöcher, D (1991) The dichotomy of anxious agitated/ impulsive versus retarded/blunted depression: A new paradigm for biological and pharmacological research.In: The Uses of Fluoxetine in Clinical Practice (Freeman, HL, ed). International Congress and Symposium series no 183, Royal Society of Medicine Services Limited, London New York, pp 3545Google Scholar
Kutas, M, McCarthy, G, Donchin, E (1977) Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science 197, 792795CrossRefGoogle ScholarPubMed
Lempérière, Τ, Lesur, A, Bonnet, D, Vicaut, E (1989) L'échelle brève d'anxiété de Tyrer en pratique extrahospitalière Première validation en langue française. L'Encéphale XV, 535542Google Scholar
Martin, DJ, Oren, Z, Boone, K (1991) Major depressives and dysthymics performance on Wisconsin Card Sorting Test. J Clin Psychol 47, 6846903.0.CO;2-G>CrossRefGoogle ScholarPubMed
Näätänen, R, Gaillard, AWK (1983) The orienting reflex and the N2 deflection of the event-related potential (ERP).In: Tutorials in ERP Research: Endogenous Components (Gaillard, AWK, Ritter, W, eds). Elsevier/North-Holland Amsterdam, pp 119141CrossRefGoogle Scholar
Pfefferbaum, A, Ford, JM, Wenegrat, BG, Roth, WT, Kopell, BS (1984) Clinical application of the P3 component of event-related potentials. I. Normal aging. Electroencephal Clin Neurophysiol 59, 85103CrossRefGoogle ScholarPubMed
Picton, TW, Stuss, DT, Champagne, SC, Nelson, RF (1984) The effect of age on human event-related potentials. Psychophysiol 21, 312325CrossRefGoogle Scholar
Puce, A, Donnan, GA, Bladin, PF (1989) Comparative effects of age on limbic and scalp P3. Electroencephalogr Clin Neurophysiol 74, 385393CrossRefGoogle ScholarPubMed
Renault, B (1983) The visual emitted potentials: clues for information processing.In: Tutorials in ERP Research: Endogenous Components (Gaillard, AWK, Ritter, W, eds). Elsevier/North-Holland Amsterdam, PP 159175CrossRefGoogle Scholar
Renault, B, Lesèvre, N (1978) Topographical study of the emitted potential obtained after the omission of an expected visual stimulus.In: Multidisciplinary perspective in event-related brain potential research (Otto, DA, ed). US Government Printing Office EPA-600/9-77-043, 202208Google Scholar
Renault, B, Ragot, R, Lesèvre, N, Rémond, A (1982) Onset and offset of brain events as indices of mental chronometry. Science 215, 14131415CrossRefGoogle ScholarPubMed
Renault, B, Kutas, M, Coles, M, Gaillard, AWK (eds) (1988) Event-related potential investigations of cognition. Biol Psychol 26, 1354CrossRefGoogle Scholar
Ritter, W, Simson, R, Vaughan HG, Jr, Friedman, D (1979) A brain event related to the making of a sensory discrimination. Science 203, 13581361CrossRefGoogle ScholarPubMed
Schliegel, S, Nieber, D, Herrman, C, Bakauski, E (1991) Latencies of the P300 component of the auditory event related potential in depression are related to the Beck-Rafaelsen Melancholia Scale but not to the Hamilton Rating Scale for Depression. Acta Psychiatr Scand 83, 438440CrossRefGoogle Scholar
Schneider, W, Shiffrin, RM (1977) Controlled and automatic human information processing I: Detection, search and attention. Psychol Rev 84, 166CrossRefGoogle Scholar
Shagass, C (1979) Psychiatric diagnostic correlates of evoked potentials. Biol Psychiatry 8, 13291334Google Scholar
Shiffrin, RM, Schneider, W (1977) Controlled and automatic human information processing II: Perceptual learning, automatic attending, and a general theory. Psychol Rev 84, 127190CrossRefGoogle Scholar
Squires, NK, Squires, KC, Hillyard, SA (1975) Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 38, 387401CrossRefGoogle ScholarPubMed
Squires, NK, Goodin, DS, Starr, A (1979) Event related potentials in development, aging and dementia.In: Human Evoked Potentials: Applications and Problems (Lehman, D, Callaway, E, eds). pp 383396CrossRefGoogle Scholar
Sternberg, DE, Jarvik, ME (1976) Memory functions in depression. Arch Gen Psychiatry 33, 219224CrossRefGoogle ScholarPubMed
Syndulko, K, Hansch, EC, Cohen, SN, Pearce, JW, Goldberg, Z, Montan, B, Tourtelotte, WW, Potvin, AR (1982) Long latency event related potentials in normal aging and dementia.In: Clinical Application of Evoked Potentials in Neurology (Courjon, J, Maugivere, F, Revol, M, eds). Raven Press, New York, pp 279286Google ScholarPubMed
Tancer, ME, Brown, TM, Evans, DL, Ekstrom, Det al(1990) Impaired effortful cognition in depression. Psychiatry Res 3, 161168CrossRefGoogle Scholar
Timsit-Berthier, M (1990) Approche neurophysiologique des états depressifs. Psychologie Medicale 22, 757763Google Scholar
Thier, P, Axmann, D, Giedke, H (1986) Slow brain potentials and psychomotor retardation in depression. Electroencephal Clin Neurophysiol 63, 570581CrossRefGoogle ScholarPubMed
Tyrer, P, Owen, RT, Cicchetti, DV (1984) The brief scale for anxiety: a subdivision of the comprehensive psychopathologicarrating scale. J Neurol Neurosurg Psychiatry 47, 970975CrossRefGoogle ScholarPubMed
Van Praag, HM, Kahn, R, Asnis, GM, Wetzler, S, Brown, SL, Bleich, A, Korn, ML (1987) Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders. J Affective Disord 13, 18CrossRefGoogle ScholarPubMed
Weingartner, H, Cohen, RM, Murphy, DL, Martello, J, Gerdt, C (1981) Cognitive processes in depression. Arch Gen Psychiatry 38, 4247CrossRefGoogle ScholarPubMed
Weingartner, H, Silberman, E (1982) Models of cognitive impairment: cognitive changes in depression. Psychophamacol Bull 18, 2742Google ScholarPubMed
Widlöocher, D (1983) Retardation: A basic emotional response?In: The Affective Disorders (Davis, JM, Maas, JW, eds). Am Psychiat Press, Washington DCGoogle Scholar
Willner, Ρ (1984) Cognitive functioning in depression: A review of theory and research. Psychol Med 14, 807823CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.