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Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients

Published online by Cambridge University Press:  13 August 2021

G. Serafini ,
G. Vazquez ,
A. Aguglia ,
A. Amerio ,
M. Pompili  and
M. Amore
G. Serafini*
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
G. Vazquez
Affiliation:
International Consortium For Bipolar & Psychotic Disorders Research, McLean Hospital, Harvard Medical School, Boston, United States of America
A. Aguglia
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
A. Amerio
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
M. Pompili
Affiliation:
Neurosciences, Mental Health And Sensory Organs, Sapienza University of Rome, Rome, Italy
M. Amore
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), Departimento di Neuroscienze, Università di Genova, Genoa, Italy
*
*Corresponding author.

Abstract

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Introduction

The patterns and clinical correlates related to antidepressant drugs (ADs) prescription for BD remain poorly understood.

Objectives

This study aimed to compare socio-demographic and clinical features of BD patients treated vs. not treated with ADs.

Methods

The sample consists of 287 currently euthymic bipolar patients. Among participants (mean age=51.9±15.02), 157 (40.1%) were receiving ADs.

Results

Based on the main findings, subjects given ADs were older and more frequently retired than those without receiving ADs. Moreover, patients given ADs were more likely to have had a first major depressive episode and present with psychotic symptoms at illness onset. Lifetime substance abuse/dependence history was less frequently reported among patients given ADs. Furthermore, ADs given patients have a higher number of affective episodes, and longer duration of their illness. Additionally, subjects treated with ADs reported higher hopelessness levels, and lower positive reinterpretations than those who were not treated with ADs. Factors associated with ADs-use by multivariate modeling were reduced personal autonomy (OR=.070), and hopelessness levels (OR=1.391).

Conclusions

These results may help clinicians to better understand the clinical correlates of BD subtypes and improve their differential management. Additional studies are needed to replicate these findings, and facilitate the differential trajectories of BD patients based on socio-demographic/clinical profile.

Disclosure

No significant relationships.

Keywords

Coping StrategiesHopelessnessantidepressant medicationsbipolar disorder
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S82
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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