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Prevalence of treatment resistant schizophrenia according to minima TRRIP criteria in a mental health catchment area in southern Spain

Published online by Cambridge University Press:  01 September 2022

L.I. Muñoz-Manchado ,
J.M. Pascual Paño ,
C. Rodríguez-Gómez ,
J.M. Mongil-Sanjuan ,
J.I. Pérez-Revuelta ,
R. Torrecilla-Olavarrieta ,
F. González-Saiz  and
J.M. Villagrán-Moreno
L.I. Muñoz-Manchado*
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
J.M. Pascual Paño
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
C. Rodríguez-Gómez
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
J.M. Mongil-Sanjuan
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
J.I. Pérez-Revuelta
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
R. Torrecilla-Olavarrieta
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
F. González-Saiz
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
J.M. Villagrán-Moreno
Affiliation:
UGC North of Cadiz, Mental Health Inpatient Unit, General Hospital., Jerez de la Frontera, Spain
*
*Corresponding author.

Abstract

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Introduction

The response to antipsychotic treatment in patients with schizophrenia varies from 14 to 34% in first episodes, and from 45 to 61% in more chronic patients. Nevertheless, the concept of treatment resistant schizophrenia (TRS) is still a matter of great controversy. Recently, an international group of experts has developed the TRRIP criteria to define treatment resistant schizophrenia (TRS), including an ultra-resistance category for clozapine resistant patients. Up till now, there is a scarcity of epidemiological data of TRS with TRRIP criteria.

Objectives

This study attempts to identify the population diagnosed of schizophrenia that fulfils the minima TRRIP criteria for TRS in our mental health catchment area.

Methods

A descriptive and retrospective study has been developed on the patients diagnosed of schizophrenia (ICD.10, F.20) in the catchment area of the Mental Health Service at Jerez Hospital between 2018 and 2019. TRRIP criteria were applied for two independent researchers and, in case of disagreement, consensus was reached by using the LEAD procedure.

Results

The total number of ICD-10 schizophrenic patients identified was 590, from a population of 456.752 in 2019. A group of these, 206 patients (35%) qualified as TRS according to the minima TRRIP criteria, 50% were positive subtype and the rest the negative one. 46.8% were treated with clozapine.

Conclusions

Consensus criteria of TRS minimise the heterogeneity of epidemiological data in literature. Our data suggest a prevalence rate of TRS lower than that of similar studies. Accordingly, a comprehensive understanding of this population would undoubtedly contribute to improve preventive and therapeutic strategies.

Disclosure

No significant relationships.

Keywords

Treatment Resistanceclozapineschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S152 - S153
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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