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S39.03 - Candidate genes and brain cortical morphology in schizophrenia

Published online by Cambridge University Press:  16 April 2020

I. Agartz ,
K. Varnäs ,
G. Lawyer ,
E.G. Jönsson ,
B. Kulle ,
R. Nesvåg ,
H. Hall ,
L. Terenius  and
P. Saetre
I. Agartz
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
K. Varnäs
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
G. Lawyer
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
E.G. Jönsson
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
B. Kulle
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
R. Nesvåg
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
H. Hall
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
L. Terenius
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden
P. Saetre
Affiliation:
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institute and Hospital, Stockholm, Sweden

Abstract

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Aim:

To investigate associations between schizophrenia candidate gene polymorphisms and regional cortical thickness and volume in patients with schizophrenia and healthy control subjects.

Methods:

Genotyping was performed using PCR and pyrosequencing techniques. Cortical morphology was analyzed by processing magnetic resonance brain images with the FreeSurfer software package. General linear model analysis was used to study associations between gene variants and cortical thickness in patients and controls, respectively. Regional cortical volumes were defined from automatic cortical parcellations. Our first studies from 96 patients with schizophrenia and 104 healthy control subjects demonstrate that polymorphisms in the brain derived neurotrophic factor (BDNF) gene may be associated with variation in frontal lobe morphology. Associations seem to be stronger in patients with schizophrenia than in healthy controls.

Type
Symposium: Genomic imaging in schizophrenia
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S58
Copyright
Copyright © European Psychiatric Association 2008
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