Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-05-31T12:29:34.126Z Has data issue: false hasContentIssue false
  • English
  • Français

Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings

Published online by Cambridge University Press:  16 April 2020

I. Michopoulos ,
I.M. Zervas ,
V.M. Papakosta ,
E. Tsaltas ,
C. Papageorgiou ,
T. Manessi ,
Y.G. Papakostas ,
L. Lykouras  and
C.R. Soldatos
I. Michopoulos*
Affiliation:
2nd Department of Psychiatry, Athens University Medical School, “Attikon” General Hospital, 1 Rimini Street, 124 62Athens, Greece
I.M. Zervas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
V.M. Papakosta
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
E. Tsaltas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
C. Papageorgiou
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
T. Manessi
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
Y.G. Papakostas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
L. Lykouras
Affiliation:
2nd Department of Psychiatry, Athens University Medical School, “Attikon” General Hospital, 1 Rimini Street, 124 62Athens, Greece
C.R. Soldatos
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
*
*Corresponding author. Tel.: +30 210 583 2426; fax: +30 210 532 6453. E-mail address: panpsyclin@attikonhospital.gr (I. Michopoulos).
Get access

Abstract

Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.

Keywords

Cambridge Neuropsychological Test Automated Battery (CANTAB)DepressionMelancholic featuresSet shifting
Type
Rapid communication
Information
European Psychiatry , Volume 21 , Issue 6 , September 2006 , pp. 361 - 363
Copyright
Copyright © Elsevier SAS 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beats, B.C., Sahakian, B.J., Levy, R.Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed Psychol. Med. 26(3)1996 591–603.CrossRefGoogle ScholarPubMed
Elliott, R., Baker, S.C., Rogers, R.D., O'Leary, D.A., Paykel, E.S., Frith, C.D.et al.Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography Psychol. Med. 27(4)1997 931–942.CrossRefGoogle ScholarPubMed
Purcell, R., Maruff, P., Kyrios, M., Pantelis, C.Neuropsychological function in young patients with unipolar major depression Psychol. Med. 27(6)1997 1277–1285.CrossRefGoogle ScholarPubMed
Weiland-Fiedler, P., Erickson, K., Waldeck, T., Luckenbaugh, D.A., Pike, D., Bonne, O.et al.Evidence for continuing neuropsychological impairments in depression J. Affect. Disord. 82(2)2004 253–258.CrossRefGoogle ScholarPubMed
Palmer, B.W., Boone, K.B., Lesser, I.M., Wohl, M.A., Berman, N., Miller, B.L.Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms J. Affect. Disord. 41(1)1996 17–24.CrossRefGoogle ScholarPubMed
Purcell, R., Maruff, P., Kyrios, M., Pantelis, C.Neuropsychological deficits in obsessive–compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls Arch. Gen. Psychiatry 55(5)1998 415–423.CrossRefGoogle ScholarPubMed
Austin, M.P., Mitchell, P., Wilhelm, K., Parker, G., Hickie, I., Brodaty, H.et al.Cognitive function in depression: a distinct pattern of frontal impairment in melancholia? Psychol. Med. 29(1)1999 73–85.CrossRefGoogle ScholarPubMed
Elliott, R., Sahakian, B.J., McKay, A.P., Herrod, J.J., Robbins, T.W., Paykel, E.S.Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance Psychol. Med. 26(5)1996 975–989.CrossRefGoogle ScholarPubMed
Mayberg, H.S.Limbic-cortical dysregulation: a proposed model of depression J. Neuropsychiatry Clin. Neurosci. 9(3)1997 471–481.Google ScholarPubMed
Rogers, M.A., Bellgrove, M.A., Chiu, E., Mileshkin, C., Bradshaw, J.L.Response selection deficits in melancholic but not nonmelancholic unipolar major depression J. Clin. Exp. Neuropsychol. 26(2)2004 169–179.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.