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Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic

Published online by Cambridge University Press:  14 April 2009

Maureen Higgins ,
Robert E. Hill  and
John D. West
Maureen Higgins
Affiliation:
MRC Human Genetics Unit, Crewe Road, Edinburgh EH14 8XU, UK Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37, Chalmers Street, Edinburgh EH3 9EW, U.K.
Robert E. Hill
Affiliation:
MRC Human Genetics Unit, Crewe Road, Edinburgh EH14 8XU, UK
John D. West*
Affiliation:
Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37, Chalmers Street, Edinburgh EH3 9EW, U.K.
*
* Corresponding author.

Summary

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Previous studies have shown that En-1, a homeobox-containing gene, maps close to or at the Dh locus in the mouse. Since homeobox-containing genes are key genes in the control of development the close proximity of En-1 to the developmentally significant gene Dh raised the possibility that the Dh mutation represented a mutant allele of En-1. A genetic analysis involving En-1, Dh, and other chromosome 1 markers (Emv-17, In and Pep-3) shows that although Dh and En-1 are closely linked they are separable by recombination (4/563). The likely gene order and recombination frequencies of these loci are: In (5.2±0.9) Emv-17 (1.1±0.4) Dh (0.7±0.4) En-1 (3.0±0.7) Pep-3. This shows that Dh is not a mutant allele of En-1.

Type
Research Article
Information
Genetics Research , Volume 60 , Issue 1 , August 1992 , pp. 53 - 60
Copyright
Copyright © Cambridge University Press 1992

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